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Clinical Efficacy and Safety of Stem Cell-Based Therapy in Treating Asherman Syndrome: A System Review and Meta-Analysis

التفاصيل البيبلوغرافية
العنوان: Clinical Efficacy and Safety of Stem Cell-Based Therapy in Treating Asherman Syndrome: A System Review and Meta-Analysis
المؤلفون: Yiming Zhao, Qifan Luo, Xiao Zhang, Yafei Qin, Jingpeng Hao, Dejun Kong, Hongda Wang, Guangming Li, Xiangying Gu, Hao Wang
المصدر: Stem Cells International, Vol 2020 (2020)
بيانات النشر: Hindawi Limited, 2020.
سنة النشر: 2020
المجموعة: LCC:Internal medicine
مصطلحات موضوعية: Internal medicine, RC31-1245
الوصف: Asherman’s Syndrome (AS) is an uncommon, acquired, and refractory gynecological disorder. Current treatment was still limited, and stem cell-based therapy has been proposed as a novel strategy for management of AS. Here, we conducted a meta-analysis of self-controlled clinical trials to assess the effectiveness and safety of stem cell-based therapy in Asherman syndrome patients who have failed in conventional treatment. We systematically searched PubMed, Embase, Cochrane, and Web of Science database (published up to October 3, 2020). Our main evaluation outcomes were menses improvement, endometrial thickness changes, pregnancy outcome, and side effects. All analyses were performed by using RevMan5.4 software. 427 studies were identified, eight of which were eligible and included in our analysis. Stem cell combined hormone therapy achieved a higher likelihood of improving menstruation (risk ratio [RR] 22.43, 95% CI: 8.03 to 62.68, P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1687-966X
1687-9678
Relation: https://doaj.org/toc/1687-966X; https://doaj.org/toc/1687-9678
DOI: 10.1155/2020/8820538
URL الوصول: https://doaj.org/article/16faa10428474abc8190fe539513f578
رقم الأكسشن: edsdoj.16faa10428474abc8190fe539513f578
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:1687966X
16879678
DOI:10.1155/2020/8820538