دورية أكاديمية
Tumor-specific chromosome mis-segregation controls cancer plasticity by maintaining tumor heterogeneity.
| العنوان: | Tumor-specific chromosome mis-segregation controls cancer plasticity by maintaining tumor heterogeneity. |
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| المؤلفون: | Yuanjie Hu, Ning Ru, Huasheng Xiao, Abhishek Chaturbedi, Neil T Hoa, Xiao-Jun Tian, Hang Zhang, Chao Ke, Fengrong Yan, Jodi Nelson, Zhenzhi Li, Robert Gramer, Liping Yu, Eric Siegel, Xiaona Zhang, Zhenyu Jia, Martin R Jadus, Charles L Limoli, Mark E Linskey, Jianhua Xing, Yi-Hong Zhou |
| المصدر: | PLoS ONE, Vol 8, Iss 11, p e80898 (2013) |
| بيانات النشر: | Public Library of Science (PLoS), 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Aneuploidy with chromosome instability is a cancer hallmark. We studied chromosome 7 (Chr7) copy number variation (CNV) in gliomas and in primary cultures derived from them. We found tumor heterogeneity with cells having Chr7-CNV commonly occurs in gliomas, with a higher percentage of cells in high-grade gliomas carrying more than 2 copies of Chr7, as compared to low-grade gliomas. Interestingly, all Chr7-aneuploid cell types in the parental culture of established glioma cell lines reappeared in single-cell-derived subcultures. We then characterized the biology of three syngeneic glioma cultures dominated by different Chr7-aneuploid cell types. We found phenotypic divergence for cells following Chr7 mis-segregation, which benefited overall tumor growth in vitro and in vivo. Mathematical modeling suggested the involvement of chromosome instability and interactions among cell subpopulations in restoring the optimal equilibrium of tumor cell types. Both our experimental data and mathematical modeling demonstrated that the complexity of tumor heterogeneity could be enhanced by the existence of chromosomes with structural abnormality, in addition to their mis-segregations. Overall, our findings show, for the first time, the involvement of chromosome instability in maintaining tumor heterogeneity, which underlies the enhanced growth, persistence and treatment resistance of cancers. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC3839911?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0080898 |
| URL الوصول: | https://doaj.org/article/16ff723591814f138d5f77f79ce7780b |
| رقم الأكسشن: | edsdoj.16ff723591814f138d5f77f79ce7780b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0080898 |