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Mamo decodes hierarchical temporal gradients into terminal neuronal fate

التفاصيل البيبلوغرافية
العنوان: Mamo decodes hierarchical temporal gradients into terminal neuronal fate
المؤلفون: Ling-Yu Liu, Xi Long, Ching-Po Yang, Rosa L Miyares, Ken Sugino, Robert H Singer, Tzumin Lee
المصدر: eLife, Vol 8 (2019)
بيانات النشر: eLife Sciences Publications Ltd, 2019.
سنة النشر: 2019
المجموعة: LCC:Medicine
LCC:Science
LCC:Biology (General)
مصطلحات موضوعية: neuronal temporal patterning, terminal selector, mushroom body, antennal lobe, Medicine, Science, Biology (General), QH301-705.5
الوصف: Temporal patterning is a seminal method of expanding neuronal diversity. Here we unravel a mechanism decoding neural stem cell temporal gene expression and transforming it into discrete neuronal fates. This mechanism is characterized by hierarchical gene expression. First, Drosophila neuroblasts express opposing temporal gradients of RNA-binding proteins, Imp and Syp. These proteins promote or inhibit chinmo translation, yielding a descending neuronal gradient. Together, first and second-layer temporal factors define a temporal expression window of BTB-zinc finger nuclear protein, Mamo. The precise temporal induction of Mamo is achieved via both transcriptional and post-transcriptional regulation. Finally, Mamo is essential for the temporally defined, terminal identity of α’/β’ mushroom body neurons and identity maintenance. We describe a straightforward paradigm of temporal fate specification where diverse neuronal fates are defined via integrating multiple layers of gene regulation. The neurodevelopmental roles of orthologous/related mammalian genes suggest a fundamental conservation of this mechanism in brain development.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2050-084X
Relation: https://elifesciences.org/articles/48056; https://doaj.org/toc/2050-084X
DOI: 10.7554/eLife.48056
URL الوصول: https://doaj.org/article/17607076d83e495f8f00c13bfd767dff
رقم الأكسشن: edsdoj.17607076d83e495f8f00c13bfd767dff
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2050084X
DOI:10.7554/eLife.48056