دورية أكاديمية

Correlation of Serum Neutrophil Gelatinaseassociated Lipocalin with Clinical Severity Score in Patients with Acute Coronary Syndrome: A Cross-sectional Study

التفاصيل البيبلوغرافية
العنوان: Correlation of Serum Neutrophil Gelatinaseassociated Lipocalin with Clinical Severity Score in Patients with Acute Coronary Syndrome: A Cross-sectional Study
المؤلفون: Sunanda Dalai, Nirupama Devi, Jhulana Kumar Jena, Jyoti Prakash Panda, Bijaya Lakshmi Nanda, Saswati Satpathy
المصدر: Journal of Clinical and Diagnostic Research, Vol 18, Iss 04, Pp 18-22 (2024)
بيانات النشر: JCDR Research and Publications Private Limited, 2024.
سنة النشر: 2024
المجموعة: LCC:Medicine
مصطلحات موضوعية: coronary angiograms, enzyme-linked immunosorbent assay, kidney injury, unstable angina, Medicine
الوصف: Introduction: Acute Coronary Syndrome (ACS) is a term that encompasses various clinical presentations such as ST-Segment Elevation Myocardial Infarction (STEMI), Non STEMI (NSTEMI), or unstable angina. Neutrophil Gelatinase-associated Lipocalin (NGAL), also known as lipocalin-2, belongs to the lipocalin category of extracellular proteins. Recent research indicates that NGAL levels are increased in different cardiac situations, regardless of the presence of acute renal injury. Aim: To compare the levels of serum NGAL and Global Registry of Acute Coronary Events (GRACE) scores between cases with ACS and Angio-negative cases, and to study the correlation of serum NGAL with the GRACE score (clinical severity score) in ACS patients. Materials and Methods: A cross-sectional study was conducted with 128 patients at the Department of Biochemistry, MKCG Medical College and Hospital, Berhampur, Odisha, India, presenting to the Cardiac Emergency Department from November 2020 to August 2021. Coronary Angiograms (CAG) were done to confirm the presence of Coronary Artery Disease (CAD), and patients were grouped accordingly as Group-1 with ACS patients and Group-2 with angiogram-negative cases. Apart from the routine work-up, including serum urea and creatinine, serum electrolytes, fasting blood sugar, lipid profile, and management, all patients underwent determination of serum NGAL levels and GRACE score at admission. The data were analysis using student’s t-test and Pearson’s correlation test. Results: Among the 128 participants (64 cases in Group-1 and 64 cases in Group-2), Group-1 comprised 37 cases of STEMI, 26 cases of NSTEMI, and one case of unstable angina. Serum NGAL levels were significantly elevated in patients with CAG-proven ACS (140.89±56.47 ng/mL) without any renal dysfunction, sepsis, or overt infection compared to patients without CAD on CAG (52.01±18.39 ng/mL) (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2249-782X
0973-709X
Relation: https://www.jcdr.net/articles/PDF/19318/66093_CE[Ra1]_F(IS)_QC(SD_RDW_IS)_PF1(RI_DK_OM)_PFA(RI_KM)_PN(KM).pdf; https://doaj.org/toc/2249-782X; https://doaj.org/toc/0973-709X
DOI: 10.7860/JCDR/2024/66093.19318
URL الوصول: https://doaj.org/article/ae1779ad13cc41018a7eb160d52b77f5
رقم الأكسشن: edsdoj.1779ad13cc41018a7eb160d52b77f5
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2249782X
0973709X
DOI:10.7860/JCDR/2024/66093.19318