دورية أكاديمية
Nanoparticle–Cartilage Interaction: Pathology-Based Intra-articular Drug Delivery for Osteoarthritis Therapy
| العنوان: | Nanoparticle–Cartilage Interaction: Pathology-Based Intra-articular Drug Delivery for Osteoarthritis Therapy |
|---|---|
| المؤلفون: | Xu Li, Bingyang Dai, Jiaxin Guo, Lizhen Zheng, Quanyi Guo, Jiang Peng, Jiankun Xu, Ling Qin |
| المصدر: | Nano-Micro Letters, Vol 13, Iss 1, Pp 1-48 (2021) |
| بيانات النشر: | SpringerOpen, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Technology |
| مصطلحات موضوعية: | Nanoparticle, Drug delivery, Osteoarthritis, Articular cartilage, Nanomedicine, Technology |
| الوصف: | Abstract Osteoarthritis is the most prevalent chronic and debilitating joint disease, resulting in huge medical and socioeconomic burdens. Intra-articular administration of agents is clinically used for pain management. However, the effectiveness is inapparent caused by the rapid clearance of agents. To overcome this issue, nanoparticles as delivery systems hold considerable promise for local control of the pharmacokinetics of therapeutic agents. Given the therapeutic programs are inseparable from pathological progress of osteoarthritis, an ideal delivery system should allow the release of therapeutic agents upon specific features of disorders. In this review, we firstly introduce the pathological features of osteoarthritis and the design concept for accurate localization within cartilage for sustained drug release. Then, we review the interactions of nanoparticles with cartilage microenvironment and the rational design. Furthermore, we highlight advances in the therapeutic schemes according to the pathology signals. Finally, armed with an updated understanding of the pathological mechanisms, we place an emphasis on the development of “smart” bioresponsive and multiple modality nanoparticles on the near horizon to interact with the pathological signals. We anticipate that the exploration of nanoparticles by balancing the efficacy, safety, and complexity will lay down a solid foundation tangible for clinical translation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2311-6706 2150-5551 |
| Relation: | https://doaj.org/toc/2311-6706; https://doaj.org/toc/2150-5551 |
| DOI: | 10.1007/s40820-021-00670-y |
| URL الوصول: | https://doaj.org/article/17bf6fdb2e2748ffac4ecaa0fef19deb |
| رقم الأكسشن: | edsdoj.17bf6fdb2e2748ffac4ecaa0fef19deb |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 23116706 21505551 |
|---|---|
| DOI: | 10.1007/s40820-021-00670-y |