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Epigenetic Mechanisms in Hepatic Stellate Cell Activation During Liver Fibrosis and Carcinogenesis

التفاصيل البيبلوغرافية
العنوان: Epigenetic Mechanisms in Hepatic Stellate Cell Activation During Liver Fibrosis and Carcinogenesis
المؤلفون: Marina Barcena-Varela, Leticia Colyn, Maite G. Fernandez-Barrena
المصدر: International Journal of Molecular Sciences, Vol 20, Iss 10, p 2507 (2019)
بيانات النشر: MDPI AG, 2019.
سنة النشر: 2019
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: Tumor microenvironment, fibrosis, hepatic stellate cells, epigenetic remodeling, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Liver fibrosis is an essential component of chronic liver disease (CLD) and hepatocarcinogenesis. The fibrotic stroma is a consequence of sustained liver damage combined with exacerbated extracellular matrix (ECM) accumulation. In this context, activation of hepatic stellate cells (HSCs) plays a key role in both initiation and perpetuation of fibrogenesis. These cells suffer profound remodeling of gene expression in this process. This review is focused on the epigenetic alterations participating in the transdifferentiation of HSCs from the quiescent to activated state. Recent advances in the field of DNA methylation and post-translational modifications (PTM) of histones (acetylation and methylation) patterns are discussed here, together with altered expression and activity of epigenetic remodelers. We also consider recent advances in translational approaches, including the use of epigenetic marks as biomarkers and the promising antifibrotic properties of epigenetic drugs that are currently being used in patients.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
Relation: https://www.mdpi.com/1422-0067/20/10/2507; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms20102507
URL الوصول: https://doaj.org/article/17d081f97a684b79be61a149318fe405
رقم الأكسشن: edsdoj.17d081f97a684b79be61a149318fe405
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
DOI:10.3390/ijms20102507