دورية أكاديمية
Salvage Mastectomy Is not the Treatment of Choice for Aggressive Subtypes of Ipsilateral Breast Cancer Recurrence: A Single-Institution Retrospective Study
| العنوان: | Salvage Mastectomy Is not the Treatment of Choice for Aggressive Subtypes of Ipsilateral Breast Cancer Recurrence: A Single-Institution Retrospective Study |
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| المؤلفون: | Damiano Gentile, Andrea Sagona, Ruggero Spoto, Davide Franceschini, Stefano Vaccari, Valeriano Vinci, Ersilia Biondi, Lorenzo Scardina, Corrado Tinterri |
| المصدر: | European Journal of Breast Health, Vol 18, Iss 4, Pp 315-322 (2022) |
| بيانات النشر: | Galenos Publishing House, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens LCC:Medicine |
| مصطلحات موضوعية: | breast cancer, triple-negative breast cancer, her2, recurrence, breast-conserving surgery, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Medicine |
| الوصف: | Objective:Patients with triple-negative (TN) or human epidermal growth factor 2 (HER2)-enriched ipsilateral breast cancer recurrence (IBCR) seem to be excluded from a second breast-conserving surgery (BCS) under the assumption that salvage mastectomy would provide better oncological outcomes. The objective of this study was to describe the clinical features of these patients, to compare the two surgical alternatives (salvage mastectomy versus second BCS) in terms of oncological results, and to identify independent factors influencing prognosis and surgical treatment.Materials and Methods:We retrospectively reviewed all the consecutive patients with histologically confirmed TN or HER2-enriched IBCR. Disease-free survival (DFS), distant disease-free survival (DDFS), overall survival (OS), and breast cancer-specific survival (BCSS) were analyzed and compared between the two groups.Results:Eighty-five patients were affected by TN or HER2-enriched IBCR. The majority of patients (72.9%) were treated with salvage mastectomy. There was no significant difference in terms of DFS between patients receiving a second BCS or mastectomy (p = 0.596). However, patients undergoing a second BCS had significantly better DDFS, OS and BCSS compared to mastectomy (p = 0.009; p = 0.002; p = 0.001, respectively). Tumor dimension |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2587-0831 |
| Relation: | http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/salvage-mastectomy-s-not-the-treatment-of-choice-f/53090; https://doaj.org/toc/2587-0831 |
| DOI: | 10.4274/ejbh.galenos.2022.2022-5-3 |
| URL الوصول: | https://doaj.org/article/17d973d3a52d41a19670ebc34aba0d03 |
| رقم الأكسشن: | edsdoj.17d973d3a52d41a19670ebc34aba0d03 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 25870831 |
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| DOI: | 10.4274/ejbh.galenos.2022.2022-5-3 |