دورية أكاديمية
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Essential oils block cellular entry of SARS-CoV-2 delta variant

التفاصيل البيبلوغرافية
العنوان: Essential oils block cellular entry of SARS-CoV-2 delta variant
المؤلفون: Luiz Torres Neto, Maria Lúcia Guerra Monteiro, José Fernández-Romero, Natalia Teleshova, James Sailer, Carlos Adam Conte Junior
المصدر: Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
بيانات النشر: Nature Portfolio, 2022.
سنة النشر: 2022
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Abstract Aiming to fill a gap in the literature, we aimed to identify the most promising EOs blocking in vitro cellular entry of SARS-CoV-2 delta variant without conferring human cytotoxicity and provide insights into the influence of their composition on these activities. Twelve EOs were characterized by gas chromatography coupled to mass spectrometry. The antiviral and cytotoxicity activities were determined using the cell-based pseudoviral entry with SARS-CoV-2 delta pseudovirus and the XTT assay in HeLa cells expressing human angiotensin-converting enzyme 2 (HeLa ACE-2), respectively. Syzygium aromaticum, Cymbopogon citratus, Citrus limon, Pelargonium graveolens, Origanum vulgare, “Illicium verum”, and Matricaria recutita showed EC50 lowered or close to 1 µg/mL but also the lowest CC50 (0.20–1.70 µg/mL), except “I. verum” (30.00 µg/mL). Among these, “I. verum”, C. limon, P. graveolens and S. aromaticum proved to be promising alternatives for SARS-CoV-2 delta variant inhibition (therapeutic index above 4), which possibly was related to the compounds (E)-anetole, limonene and beta-pinene, citronellol, and eugenol, respectively.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-022-25342-8
URL الوصول: https://doaj.org/article/17da643291bf436fa357f84662b20c2d
رقم الأكسشن: edsdoj.17da643291bf436fa357f84662b20c2d
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-022-25342-8