دورية أكاديمية
Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis.
| العنوان: | Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis. |
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| المؤلفون: | Sara Tengvall, Tove Eneljung, Pernilla Jirholt, Olof Turesson, Kajsa Wing, Rikard Holmdahl, Jan Kihlberg, Anna Stern, Inga-Lill Mårtensson, Louise Henningsson, Kenth Gustafsson, Inger Gjertsson |
| المصدر: | PLoS ONE, Vol 11, Iss 5, p e0154630 (2016) |
| بيانات النشر: | Public Library of Science (PLoS), 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Here, we investigate induction of immunological tolerance by lentiviral based gene therapy in a mouse model of rheumatoid arthritis, collagen II-induced arthritis (CIA). Targeting the expression of the collagen type II (CII) to antigen presenting cells (APCs) induced antigen-specific tolerance, where only 5% of the mice developed arthritis as compared with 95% of the control mice. In the CII-tolerized mice, the proportion of Tregs as well as mRNA expression of SOCS1 (suppressors of cytokine signaling 1) increased at day 3 after CII immunization. Transfer of B cells or non-B cell APC, as well as T cells, from tolerized to naïve mice all mediated a certain degree of tolerance. Thus, sustainable tolerance is established very early during the course of arthritis and is mediated by both B and non-B cells as APCs. This novel approach for inducing tolerance to disease specific antigens can be used for studying tolerance mechanisms, not only in CIA but also in other autoimmune diseases. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC4861286?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0154630 |
| URL الوصول: | https://doaj.org/article/18108702b4af416fa7887cf88191d827 |
| رقم الأكسشن: | edsdoj.18108702b4af416fa7887cf88191d827 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0154630 |