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Real-world efficacy and safety of liposomal irinotecan plus fluorouracil/leucovorin in patients with metastatic pancreatic adenocarcinoma: a study by the Korean Cancer Study Group

التفاصيل البيبلوغرافية
العنوان: Real-world efficacy and safety of liposomal irinotecan plus fluorouracil/leucovorin in patients with metastatic pancreatic adenocarcinoma: a study by the Korean Cancer Study Group
المؤلفون: Changhoon Yoo, Hyeon-Su Im, Kyu-pyo Kim, Do-Youn Oh, Kyung-Hun Lee, Hong Jae Chon, Joo Hoon Kim, Myoungjoo Kang, Ilhwan Kim, Guk Jin Lee, Sung Yong Oh, Younak Choi, Hye Jin Choi, Seung Tae Kim, Joon Oh Park, Baek-Yeol Ryoo
المصدر: Therapeutic Advances in Medical Oncology, Vol 11 (2019)
بيانات النشر: SAGE Publishing, 2019.
سنة النشر: 2019
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Background: Liposomal irinotecan (nal-IRI) plus 5-fluorouracil and leucovorin (5-FU/LV) was effective and well-tolerated in patients with metastatic pancreatic adenocarcinoma (mPAC) that progressed on gemcitabine-based therapy in the global NAPOLI-1 trial. Real-world data may further clarify the outcomes and safety profile of nal-IRI + 5-FU/LV in clinical practice. Methods: This retrospective analysis included patients with mPAC who received nal-IRI + 5-FU/LV following gemcitabine-based therapy under a Managed Access Program in Korea. Results: From January 2017 to April 2018, 86 patients across 10 institutions received nal-IRI + 5-FU/LV (median age, 61 years; 60% male; ECOG performance status, 0–1). A total of 35 (41%) and 51 (59%) patients had received less than two and two or more lines of chemotherapy before inclusion, respectively. At a median follow up of 6.4 months, median overall survival (OS) was 9.4 months (95% confidence interval [CI] 7.4–11.4) and median progression-free survival (PFS) was 3.5 months (95% CI 1.3–5.7). Six-month OS and PFS rates were 65.1% and 37.5%, respectively. Objective response and disease control rates were 10% and 55%, respectively. Most common grade 3–4 toxicities were neutropenia (37.2%), nausea (10.5%), vomiting (9.3%), anorexia (8.1%) and diarrhoea (4.7%). Conclusion: Real-life data for Korean patients indicate that, consistent with NAPOLI-1, nal-IRI + 5-FU/LV is effective and well-tolerated in patients with mPAC that progressed on gemcitabine-based therapy.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1758-8359
17588359
Relation: https://doaj.org/toc/1758-8359
DOI: 10.1177/1758835919871126
URL الوصول: https://doaj.org/article/185c01d47e16433f8d481211246e924a
رقم الأكسشن: edsdoj.185c01d47e16433f8d481211246e924a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17588359
DOI:10.1177/1758835919871126