دورية أكاديمية

The autologous chondral platelet-rich plasma matrix implantation. A new therapy in cartilage repair and regeneration: macroscopic and biomechanical study in an experimental sheep model

التفاصيل البيبلوغرافية
العنوان: The autologous chondral platelet-rich plasma matrix implantation. A new therapy in cartilage repair and regeneration: macroscopic and biomechanical study in an experimental sheep model
المؤلفون: Pau Peláez-Gorrea, Elena Damiá-Giménez, Mónica Rubio-Zaragoza, Belén Cuervo-Serrato, Ángel María Hernández-Guerra, Laura Miguel-Pastor, Ayla Del Romero-Martínez, Joaquín Sopena-Juncosa, Marta Torres-Torrillas, Angelo Santana, Ramón Cugat-Bertomeu, José Manuel Vilar-Guereño, Jose Maria Carrillo-Poveda
المصدر: Frontiers in Veterinary Science, Vol 10 (2023)
بيانات النشر: Frontiers Media S.A., 2023.
سنة النشر: 2023
المجموعة: LCC:Veterinary medicine
مصطلحات موضوعية: cartilage regeneration, regenerative medicine, plasma rich in growth factors, autologous platelet rich plasma matrix implantation, force platform, symmetry index, Veterinary medicine, SF600-1100
الوصف: IntroductionArticular cartilage injuries are a severe problem, and the treatments for these injuries are complex. The present study investigates a treatment for full-thickness cartilage defects called Autologous Chondral Platelet Rich Plasma Matrix Implantation (PACI) in a sheep model.MethodsChondral defects 8 mm in diameter were surgically induced in the medial femoral condyles of both stifles in eight healthy sheep. Right stifles were treated with PACI and an intraarticular injection with a plasma rich in growth factors (PRGF) solution [treatment group (TRT)], while an intraarticular injection of Ringer’s lactate solution was administered in left stifles [Control group (CT)]. The limbs’ function was objectively assessed with a force platform to obtain the symmetry index, comparing both groups. After 9 and 18 months, the lesions were macroscopically evaluated using the International Cartilage Repair Society and Goebel scales.ResultsRegarding the symmetry index, the TRT group obtained results similar to those of healthy limbs at 9 and 18 months after treatment. Regarding the macroscopic assessment, the values obtained by the TRT group were very close to those of normal cartilage and superior to those obtained by the CT group at 9 months.ConclusionThis new bioregenerative treatment modality can regenerate hyaline articular cartilage. High functional outcomes have been reported, together with a good quality repair tissue in sheep. Therefore, PACI treatment might be a good therapeutic option for full-thickness chondral lesions.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2297-1769
Relation: https://www.frontiersin.org/articles/10.3389/fvets.2023.1223825/full; https://doaj.org/toc/2297-1769
DOI: 10.3389/fvets.2023.1223825
URL الوصول: https://doaj.org/article/c186dfbe0b8447b5b727456eac2bfb43
رقم الأكسشن: edsdoj.186dfbe0b8447b5b727456eac2bfb43
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:22971769
DOI:10.3389/fvets.2023.1223825