دورية أكاديمية
Strain-, Sex-, and Time-Dependent Antidepressant-like Effects of Cannabidiol
| العنوان: | Strain-, Sex-, and Time-Dependent Antidepressant-like Effects of Cannabidiol |
|---|---|
| المؤلفون: | Gabriela P. Silote, Michelle C. Gatto, Amanda Eskelund, Francisco S. Guimarães, Gregers Wegener, Sâmia R. L. Joca |
| المصدر: | Pharmaceuticals, Vol 14, Iss 12, p 1269 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | cannabidiol, S-ketamine, sex, mice strain, Flinders Sensitive Line rats, Flinders Resistant Lines rats, Medicine, Pharmacy and materia medica, RS1-441 |
| الوصف: | Cannabidiol (CBD) is a non-intoxicating compound extracted from Cannabis sativa, showing antidepressant-like effects in different rodent models. However, inconsistent results have been described depending on the species and the strain used to assess depressive-like behavior. Moreover, only a few studies investigated the effect of CBD in female rodents. Therefore, we aimed to (i) investigate the effects of CBD in two different strains of mice (Swiss and C57BL/6) and a rat model of depression based on selective breeding (Flinders Sensitive and Resistant Lines, FSL and FRL) subjected to tests predictive of antidepressant-like effects and (ii) investigate the influence of sex in the effects of CBD in both mice and rats. CBD induced an antidepressant-like effect in male Swiss but not in female Swiss or C57BL/6 mice in the tail suspension test (TST). In male FSL rats, CBD produced an antidepressant-like effect 1 h post injection. However, in female FSL, CBD induced a bimodal effect, increasing the immobility time at 1 h and decreasing it at 2 h. In conclusion, strain, sex, and administration time affect CBD’s behavioral response to rodents exposed to tests predictive of antidepressant effects. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1424-8247 |
| Relation: | https://www.mdpi.com/1424-8247/14/12/1269; https://doaj.org/toc/1424-8247 |
| DOI: | 10.3390/ph14121269 |
| URL الوصول: | https://doaj.org/article/c187f292a4ac4f7289a45d8bee5f88e7 |
| رقم الأكسشن: | edsdoj.187f292a4ac4f7289a45d8bee5f88e7 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14248247 |
|---|---|
| DOI: | 10.3390/ph14121269 |