دورية أكاديمية
NADPH-oxidases as potential pharmacological targets for thrombosis and depression comorbidity
| العنوان: | NADPH-oxidases as potential pharmacological targets for thrombosis and depression comorbidity |
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| المؤلفون: | Patrizia Amadio, Leonardo Sandrini, Marta Zarà, Silvia S. Barbieri, Alessandro Ieraci |
| المصدر: | Redox Biology, Vol 70, Iss , Pp 103060- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | NOX, Platelets, Endothelium, Neurons, Microglia, Psychiatry disorders, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | There is a complex interrelationship between the nervous system and the cardiovascular system. Comorbidities of cardiovascular diseases (CVD) with mental disorders, and vice versa, are prevalent. Adults with mental disorders such as anxiety and depression have a higher risk of developing CVD, and people with CVD have an increased risk of being diagnosed with mental disorders.Oxidative stress is one of the many pathways associated with the pathophysiology of brain and cardiovascular disease. Nicotinamide adenine dinucleotide phosphate oxidase (NOX) is one of the major generators of reactive oxygen species (ROS) in mammalian cells, as it is the enzyme that specifically produces superoxide.This review summarizes recent findings on the consequences of NOX activation in thrombosis and depression. It also discusses the therapeutic effects and pharmacological strategies of NOX inhibitors in CVD and brain disorders. A better comprehension of these processes could facilitate the development of new therapeutic approaches for the prevention and treatment of the comorbidity of thrombosis and depression. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2213-2317 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2213231724000363; https://doaj.org/toc/2213-2317 |
| DOI: | 10.1016/j.redox.2024.103060 |
| URL الوصول: | https://doaj.org/article/1882e7fc398a46c59acb8e2028f71328 |
| رقم الأكسشن: | edsdoj.1882e7fc398a46c59acb8e2028f71328 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22132317 |
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| DOI: | 10.1016/j.redox.2024.103060 |