دورية أكاديمية
Effects of the Type and Volume of Physical Activity on Leukocyte Telomere Length in Middle-Aged Men
العنوان: | Effects of the Type and Volume of Physical Activity on Leukocyte Telomere Length in Middle-Aged Men |
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المؤلفون: | Yun-A Shin, Chang-Sun Kim, Sang-Hyun Lee, Yong-Woo Lee, Jun-Soo Kim, Dong-Ho Park |
المصدر: | 운동과학, Vol 30, Iss 4, Pp 462-471 (2021) |
بيانات النشر: | The Korean Society of Exercise Physiology, 2021. |
سنة النشر: | 2021 |
المجموعة: | LCC:Nutrition. Foods and food supply LCC:Biochemistry |
مصطلحات موضوعية: | middle-aged men, telomere length, type of physical activity, telomerase, mtdna copy number, Nutrition. Foods and food supply, TX341-641, Biochemistry, QD415-436 |
الوصف: | PURPOSE Leukocyte telomere length (LTL) is a potential indicator of cellular senescence. However, its relationship with the type and volume of regular exercise is unclear. Therefore, we investigated the effects of the type and volume of long-term regular exercise on the LTL in middle-aged men (N=109, mean age=44.7±4.1 years [range: 40-56 years]). METHODS For all participants, the volume of physical activity (PA) was evaluated using a self-report questionnaire, and blood samples were collected simultaneously. We cross-sectionally examined the associations among the type and volume of PA, LTL, telomerase activity (TA), mitochondrial DNA copy number (mtDNA), and body composition in three groups: 1) bodybuilders (BBs) with at least 5 years of athletic experience (n=36, mean age: 42.3±3.3 years [40-51 years]), 2) cyclists (CCs) with an athletic career similar to that of the BBs (n=37, mean age: 45.4±4.4 years [range: 40-53 years]), and 3) healthy ordinary people (CON; n=36, mean age: 46.3±3.3 years [range: 40-56 years]). RESULTS The LTL showed a significant positive correlation with the volume of PA (r=.285, p=.003), regardless of the type of PA. Furthermore, the LTLs were longer in the BB (p=.007) and CC (p=.003) groups (who performed moderate-to-vigorous PA for 150 minutes or more per week) than in the CON group. Conversely, the TA was significantly higher in the BB group (p=.009) than in the CON group; however, it only tended to be high in the CC group (p=.115). There were no intergroup differences in both the mtDNA (p=.127) and 8-hydroxydeoxyguanosine (p=.289) levels. CONCLUSIONS The TA was found to increase, and thus prevent telomere loss, in middle-aged men who performed PA of moderateto-vigorous intensity, regardless of the PA type. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | Korean |
تدمد: | 1226-1726 2384-0544 |
Relation: | http://www.ksep-es.org/upload/pdf/ksep-2021-00437.pdf; https://doaj.org/toc/1226-1726; https://doaj.org/toc/2384-0544 |
DOI: | 10.15857/ksep.2021.00437 |
URL الوصول: | https://doaj.org/article/18a20ee7fa274564b791f223129c702f |
رقم الأكسشن: | edsdoj.18a20ee7fa274564b791f223129c702f |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 12261726 23840544 |
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DOI: | 10.15857/ksep.2021.00437 |