دورية أكاديمية
O6-methylguanine-DNA Methyltransferase Promoter Methylation in Patients with Rectal Adenocarcinoma After Chemoradiotherapy Treatment: Clinical Implications
| العنوان: | O6-methylguanine-DNA Methyltransferase Promoter Methylation in Patients with Rectal Adenocarcinoma After Chemoradiotherapy Treatment: Clinical Implications |
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| المؤلفون: | Jaime A. Oliver, Jaime Gómez-Millán, Jose A. Medina, Laura Cabeza, Gloria Perazzoli, Cristina Jimenez-Luna, Kevin Doello, Raúl Ortiz |
| المصدر: | Balkan Medical Journal, Vol 36, Iss 5, Pp 283-286 (2019) |
| بيانات النشر: | Galenos Publishing House, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Chemoradiotherapy, O6-methylguanine-DNA methyltransferase, rectal adenocarcinoma, Medicine |
| الوصف: | Aims: To analyze the clinical relevance of O6-methylguanine-DNA methyltransferase in rectal adenocarcinoma treated with chemoradiotherapy followed by surgery. Methods: Tissue samples from 29 rectal adenocarcinoma patients were obtained after chemoradiotherapy. O6-methylguanine-DNA methyltransferase promoter methylation status was established by methylation-specific polymerase chain reaction. O6-methylguanine-DNA methyltransferase protein levels were determined by immunohistochemistry. Clinicopathologic variables, including treatment regression grade, recurrence, lymph node invasion, and stage and differentiation grade of the tumor, were determined. Results: The O6-methylguanine-DNA methyltransferase gene promoter was methylated in 81.5% of samples. Most patients (88.9%) showed low O6-methylguanine-DNA methyltransferase protein expression. O6-methylguanine-DNA methyltransferase methylation status was not correlated with any of the clinicopathological variables determined in rectal adenocarcinomas selected for chemoradiotherapy. Conclusion: O6-methylguanine-DNA methyltransferase methylation status is not correlated with clinicopathologic variables examined in rectal adenocarcinoma selected for chemoradiotherapy, although its role as a biomarker awaits further investigation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2146-3123 2146-3131 |
| Relation: | http://balkanmedicaljournal.org/text.php?lang=en&id=2100; https://doaj.org/toc/2146-3123; https://doaj.org/toc/2146-3131 |
| DOI: | 10.4274/balkanmedj.galenos.2019.2018.12.93 |
| URL الوصول: | https://doaj.org/article/18a282223f4c45379944876be55e2d1f |
| رقم الأكسشن: | edsdoj.18a282223f4c45379944876be55e2d1f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21463123 21463131 |
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| DOI: | 10.4274/balkanmedj.galenos.2019.2018.12.93 |