دورية أكاديمية
A 'Proteoglycan Targeting Strategy' for the Scintigraphic Imaging and Monitoring of the Swarm Rat Chondrosarcoma Orthotopic Model
| العنوان: | A 'Proteoglycan Targeting Strategy' for the Scintigraphic Imaging and Monitoring of the Swarm Rat Chondrosarcoma Orthotopic Model |
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| المؤلفون: | Caroline Peyrode, François Gouin, Aurélien Vidal, Philippe Auzeloux, Sophie Besse, Marie-Mélanie Dauplat, Serge Askienazy, Dominique Heymann, Jean-Michel Chezal, Françoise Redini, Elisabeth Miot-Noirault |
| المصدر: | Sarcoma, Vol 2011 (2011) |
| بيانات النشر: | Wiley, 2011. |
| سنة النشر: | 2011 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Our lab developed 99mTc-NTP 15-5 radiotracer as targeting proteoglycans (PGs) for the scintigraphic imaging of joint. This paper reports preclinical results of 99mTc-NTP 15-5 imaging of an orthotopic model of Swarm rat chondrosarcoma (SRC). 99mTc-NTP 15-5 imaging of SRC-bearing and sham-operated animals was performed and quantified at regular intervals after surgery and compared to bone scintigraphy and tumoural volume. Tumours were characterized by histology and PG assay. SRC exhibited a significant 99mTc-NTP 15-5 uptake at very early stage after implant (with tumour/muscle ratio of 1.61 ± 0.14), whereas no measurable tumour was evidenced. As tumour grew, mean tumour/muscle ratio was increased by 2.4, between the early and late stage of pathology. Bone scintigraphy failed to image chondrosarcoma, even at the later stage of study. 99mTc-NTP 15-5 imaging provided a suitable set of quantitative criteria for the in vivo characterization of chondrosarcoma behaviour in bone environment, useful for achieving a greater understanding of the pathology. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1357-714X 1369-1643 |
| Relation: | https://doaj.org/toc/1357-714X; https://doaj.org/toc/1369-1643 |
| DOI: | 10.1155/2011/691608 |
| URL الوصول: | https://doaj.org/article/18dc8abc58d6445883ef0a4a68a096fe |
| رقم الأكسشن: | edsdoj.18dc8abc58d6445883ef0a4a68a096fe |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1357714X 13691643 |
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| DOI: | 10.1155/2011/691608 |