The welfare and ethics of laboratory animals in drug development has attracted increasing attention, and how to treat animals well has become an important topic. Blood microsampling overcomes several disadvantages of conventional large-volume blood sampling methods, such as complex operation, great harm to animals and high requirement on rodent quantity, and has great advantages in animal welfare, scientificity and cost. Therefore, its application is regarded as an important practice to implement the 3Rs. This article reviewed the latest research progress of blood microsampling, and its advantages and challenges in non-clinical studies in order to promote the wider application of this new technique in this field.
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