دورية أكاديمية
Cenicriviroc, a dual CCR2 and CCR5 antagonist leads to a reduction in plasma fibrotic biomarkers in persons living with HIV on antiretroviral therapy
| العنوان: | Cenicriviroc, a dual CCR2 and CCR5 antagonist leads to a reduction in plasma fibrotic biomarkers in persons living with HIV on antiretroviral therapy |
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| المؤلفون: | S. Bowler, C. Siriwardhana, B. L. Mitchell, M. L. D’Antoni, D. Ogata-Arakaki, S. Souza, R. Yee, L. M. A. Gangcuangco, D. C. Chow, L. C. Ndhlovu, C. Shikuma |
| المصدر: | HIV Research & Clinical Practice, Vol 20, Iss 4-5, Pp 123-129 (2019) |
| بيانات النشر: | Taylor & Francis Group, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | hiv, inflammation, fibrosis, chemokines, ccr2, ccr5, Infectious and parasitic diseases, RC109-216 |
| الوصف: | Background: Chronic HIV is associated with increased inflammation and tissue fibrosis despite suppressive antiretroviral therapy (ART). Monocytes and macrophages have been implicated in the pathogenesis of fibrosis, facilitated by chemokine receptor interactions. Methods: We assessed systemic fibrotic biomarkers (transforming growth factor beta-1 [TGF-β1], thrombospondin-1 [TSP-1], C-terminal pro-peptide of collagen type I [CICP], and IL-11) in banked plasma from a previously published 24-week open-label trial of cenicriviroc (CVC), a dual CCR2/CCR5 antagonist, among persons living with HIV (PLWH) on stable ART with undetectable plasma HIV RNA ( 0.05), while TSP-1 remained elevated in PLWH (p = 0.009) compared to controls. Conclusions: PLWH had higher levels of the plasma fibrotic markers TGF-β1, TSP-1, and CICP. After 24 weeks of CVC, fibrotic markers generally returned to levels comparable to HIV-uninfected controls. Dual CCR2 and CCR5 blockade may ameliorate the detrimental fibrotic events that persist in treated HIV. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2578-7470 25787489 |
| Relation: | https://doaj.org/toc/2578-7470 |
| DOI: | 10.1080/25787489.2020.1719319 |
| URL الوصول: | https://doaj.org/article/1943ada5fcc04469a972bdd3be6591bc |
| رقم الأكسشن: | edsdoj.1943ada5fcc04469a972bdd3be6591bc |
| قاعدة البيانات: | Directory of Open Access Journals |
PDF full text from Publisher | تدمد: | 25787470 25787489 |
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| DOI: | 10.1080/25787489.2020.1719319 |