دورية أكاديمية
Radiotherapy combined with deep regional hyperthermia in elderly and frail patients with muscle-invasive bladder cancer: quality analysis of hyperthermia and impact on clinical results
| العنوان: | Radiotherapy combined with deep regional hyperthermia in elderly and frail patients with muscle-invasive bladder cancer: quality analysis of hyperthermia and impact on clinical results |
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| المؤلفون: | Adela Ademaj, Emsad Puric, Dietmar Marder, Olaf Timm, Thomas Kern, Roger A. Hälg, Susanne Rogers, Oliver Riesterer |
| المصدر: | International Journal of Hyperthermia, Vol 40, Iss 1 (2023) |
| بيانات النشر: | Taylor & Francis Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medical technology |
| مصطلحات موضوعية: | Radiotherapy, deep regional hyperthermia, muscle-invasive bladder cancer, temperature metrics, thermal dose, hyperthermia sessions, Medical technology, R855-855.5 |
| الوصف: | AbstractPurpose: Radiotherapy (RT) in combination with deep regional hyperthermia (HT) after transurethral removal of bladder tumor (TURBT) can be offered to elderly and frail patients with muscle-invasive bladder cancer (MIBC).Methods: In total, 21 patients (mean age 84 years) with unifocal or multifocal MIBC received radiation to a dose of 48–50 Gy/16–20 fractions with weekly HT. The primary endpoint was the variation in temperature metrics, thermal dose expressed as cumulative equivalent minutes at 43 °C when the measured temperature is T90 (CEM43T90) and net power applied in target volume per each HT session. Secondary endpoints were three-year overall survival (OS), disease-free survival (DFS), local progression-free survival (LPFS) and toxicity.Results: The temperature metrics, CEM43T90, mean and maximum net power applied did not differ significantly among the HT sessions of the 21 patients. With a median follow-up of 65 months, 52% (95% CI 32–72%) of patients had died 3 years after treatment. The three-year DFS and LPFS rates were 62% (95%CI 41–79%) and 81% (95%CI 60–92%), respectively. The three-year bladder preservation rate was 100%. Three out of four patients with local failure received a thermal dose CEM43T90 below a median of 2.4 min. The rates of acute and late grade-3 toxicities were 10% and 14%, respectively.Conclusion: The reproducibility of HT parameters between sessions was high. A moderately high CEM43T90 (> 2.4 min) for each HT session seems to be preferable for local control. RT combined with HT is a promising organ-preservation therapy for elderly and frail MIBC patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 02656736 1464-5157 0265-6736 |
| Relation: | https://doaj.org/toc/0265-6736; https://doaj.org/toc/1464-5157 |
| DOI: | 10.1080/02656736.2023.2275540 |
| URL الوصول: | https://doaj.org/article/1950480afb7247bb99bb52c11fbda94a |
| رقم الأكسشن: | edsdoj.1950480afb7247bb99bb52c11fbda94a |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 02656736 14645157 |
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| DOI: | 10.1080/02656736.2023.2275540 |