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Collagen-Sealed Polyester Vascular Prostheses Functionalized by Polycatecholamine Coatings

التفاصيل البيبلوغرافية
العنوان: Collagen-Sealed Polyester Vascular Prostheses Functionalized by Polycatecholamine Coatings
المؤلفون: Anna Michalicha, Cristina Canal, Albert Espona-Noguera, Mateusz Piet, Barbara Budzyńska, Stanislaw Przywara, Anna Belcarz
المصدر: International Journal of Molecular Sciences, Vol 23, Iss 16, p 9369 (2022)
بيانات النشر: MDPI AG, 2022.
سنة النشر: 2022
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: collagen-sealed vascular prostheses, poly(L-DOPA), gentamicin, glycerol, antibacterial, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Collagen-sealed polyester (PET) prostheses are commonly used in reconstructive vascular surgery due to their self-sealing properties. To prevent post-surgical infection, different modification methods have been tested but so far none have showed long-term satisfactory efficiency. For this reason, in the present study, a commercial collagen-sealed PET prosthesis was coated by a highly adhesive poly (L-DOPA) layer maintaining the sealing protein without losing the original properties and functionality. This modified (as proven by SEM, FTIR, XPS and contact angle) graft exhibited comparable wettability and elasticity as pristine commercial graft, as well as reduced hemolysis-inducing effect, lowered toxicity against human endothelial cells and reduced toxicity in Danio rerio model. Poly (L-DOPA)-coated grafts were shown to bind six times more aminoglycoside antibiotic (gentamicin) than pristine graft. Poly (L-DOPA)-coated antibiotic-bound prostheses exhibited an improved antibacterial activity (bacterial growth inhibition and anti-adhesive capacity) in comparison with pristine antibiotic-bound graft. Overall, poly (L-DOPA)-coatings deposited on PET vascular grafts can effectively functionalize collagen-sealed prostheses without the loss of protein sealing layer and allow for antibiotics incorporation to provide higher safety in biomedical applications.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
1661-6596
Relation: https://www.mdpi.com/1422-0067/23/16/9369; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms23169369
URL الوصول: https://doaj.org/article/19825f82a9224f8fbc42d9f7b66a8537
رقم الأكسشن: edsdoj.19825f82a9224f8fbc42d9f7b66a8537
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
16616596
DOI:10.3390/ijms23169369