دورية أكاديمية
Collagen-Sealed Polyester Vascular Prostheses Functionalized by Polycatecholamine Coatings
العنوان: | Collagen-Sealed Polyester Vascular Prostheses Functionalized by Polycatecholamine Coatings |
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المؤلفون: | Anna Michalicha, Cristina Canal, Albert Espona-Noguera, Mateusz Piet, Barbara Budzyńska, Stanislaw Przywara, Anna Belcarz |
المصدر: | International Journal of Molecular Sciences, Vol 23, Iss 16, p 9369 (2022) |
بيانات النشر: | MDPI AG, 2022. |
سنة النشر: | 2022 |
المجموعة: | LCC:Biology (General) LCC:Chemistry |
مصطلحات موضوعية: | collagen-sealed vascular prostheses, poly(L-DOPA), gentamicin, glycerol, antibacterial, Biology (General), QH301-705.5, Chemistry, QD1-999 |
الوصف: | Collagen-sealed polyester (PET) prostheses are commonly used in reconstructive vascular surgery due to their self-sealing properties. To prevent post-surgical infection, different modification methods have been tested but so far none have showed long-term satisfactory efficiency. For this reason, in the present study, a commercial collagen-sealed PET prosthesis was coated by a highly adhesive poly (L-DOPA) layer maintaining the sealing protein without losing the original properties and functionality. This modified (as proven by SEM, FTIR, XPS and contact angle) graft exhibited comparable wettability and elasticity as pristine commercial graft, as well as reduced hemolysis-inducing effect, lowered toxicity against human endothelial cells and reduced toxicity in Danio rerio model. Poly (L-DOPA)-coated grafts were shown to bind six times more aminoglycoside antibiotic (gentamicin) than pristine graft. Poly (L-DOPA)-coated antibiotic-bound prostheses exhibited an improved antibacterial activity (bacterial growth inhibition and anti-adhesive capacity) in comparison with pristine antibiotic-bound graft. Overall, poly (L-DOPA)-coatings deposited on PET vascular grafts can effectively functionalize collagen-sealed prostheses without the loss of protein sealing layer and allow for antibiotics incorporation to provide higher safety in biomedical applications. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1422-0067 1661-6596 |
Relation: | https://www.mdpi.com/1422-0067/23/16/9369; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
DOI: | 10.3390/ijms23169369 |
URL الوصول: | https://doaj.org/article/19825f82a9224f8fbc42d9f7b66a8537 |
رقم الأكسشن: | edsdoj.19825f82a9224f8fbc42d9f7b66a8537 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 14220067 16616596 |
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DOI: | 10.3390/ijms23169369 |