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Curcumin ameliorates gestational diabetes in mice partly through activating AMPK

التفاصيل البيبلوغرافية
العنوان: Curcumin ameliorates gestational diabetes in mice partly through activating AMPK
المؤلفون: Xuehong Lu, Fei Wu, Mengxue Jiang, Xiujuan Sun, Geng Tian
المصدر: Pharmaceutical Biology, Vol 57, Iss 1, Pp 250-254 (2019)
بيانات النشر: Taylor & Francis Group, 2019.
سنة النشر: 2019
المجموعة: LCC:Therapeutics. Pharmacology
مصطلحات موضوعية: gsh, sod, cat, ampk, hdac4, glucose-6-phosphatase, Therapeutics. Pharmacology, RM1-950
الوصف: Context: In vitro and in vivo research has shown that curcumin can alleviate diabetes and the relevant complications. Objective: To investigate the effect of curcumin on gestational diabetes (GD). Materials and methods: C57 BL/KsJdb/+(db/+) mice and C57 BL/KsJ+/+ mice (10–12 weeks old) were divided into four groups (n = 15): normal pregnancy (C57 BL/KsJ+/+), GD (C57 BL/KsJdb/+), GD plus low dose curcumin (50 mg/kg, orally gavage every day) and GD plus high dose curcumin (100 mg/kg, orally gavage every day). The tolerance of glucose and insulin were measured on gestation day 10. Body weight at birth and litter size of offspring were investigated, and the expression of oxidative stress factors [thiobarbituric acid reactive substance (TBARS), glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT)] and AMP-activated protein kinase (AMPK), phospho-AMPK, histone deacetylases 4 (HDAC4), pHDAC4 and glucose-6-phosphatase (G6Pase) in the livers were analyzed by ELISA and Western blot on gestation day 20. Results: High dose curcumin could partly ameliorate the intolerance of glucose and insulin, and completely restore the litter size and the body weight of GD mice through decreased TBARS expression (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1388-0209
1744-5116
13880209
Relation: https://doaj.org/toc/1388-0209; https://doaj.org/toc/1744-5116
DOI: 10.1080/13880209.2019.1594311
URL الوصول: https://doaj.org/article/19a1b375a69a458588d282f1b7ae09ec
رقم الأكسشن: edsdoj.19a1b375a69a458588d282f1b7ae09ec
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:13880209
17445116
DOI:10.1080/13880209.2019.1594311