دورية أكاديمية
Association between poor tolerability of antidepressant treatment and brain functional activation in youth at risk for bipolar disorder
| العنوان: | Association between poor tolerability of antidepressant treatment and brain functional activation in youth at risk for bipolar disorder |
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| المؤلفون: | Fabiano G. Nery, Sheela L. Masifi, Jeffrey R. Strawn, Luis R. Duran, Wade A. Weber, Jeffrey A. Welge, Caleb M. Adler, Stephen M. Strakowski, Melissa P. DelBello |
| المصدر: | Brazilian Journal of Psychiatry, Vol 43, Iss 1, Pp 70-74 (2020) |
| بيانات النشر: | Associação Brasileira de Psiquiatria (ABP), 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Psychiatry |
| مصطلحات موضوعية: | Bipolar disorder, antidepressants, adverse events, functional magnetic resonance imaging, amygdala, Psychiatry, RC435-571 |
| الوصف: | Objective: To investigate whether poor antidepressant tolerability is associated with functional brain changes in children and adolescents of parents with bipolar I disorder (at-risk youth). Methods: Seventy-three at-risk youth (ages 9-20 years old) who participated in a prospective study and had an available baseline functional magnetic resonance imaging (fMRI) scan were included. Research records were reviewed for the incidence of adverse reactions related to antidepressant exposure during follow-up. The sample was divided among at-risk youth without antidepressant exposure (n=21), at-risk youth with antidepressant exposure and no adverse reaction (n=12), at-risk youth with antidepressant-related adverse reaction (n=21), and healthy controls (n=20). The fMRI task was a continuous performance test with emotional distracters. Region-of-interest mean activation in brain areas of the fronto-limbic emotional circuit was compared among groups. Results: Right amygdala activation in response to emotional distracters significantly differed among groups (F3,66 = 3.1, p = 0.03). At-risk youth with an antidepressant-related adverse reaction had the lowest amygdala activation, while at-risk youth without antidepressant exposure had the highest activation (p = 0.004). Conclusions: Decreased right amygdala activation in response to emotional distracters is associated with experiencing an antidepressant-related adverse reaction in at-risk youth. Further studies to determine whether amygdala activation is a useful biomarker for antidepressant-related adverse events are needed. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Portuguese |
| تدمد: | 1809-452X 1516-4446 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462021000100013&tlng=en; http://www.scielo.br/pdf/rbp/v43n1/1516-4446-rbp-1516444620190803.pdf; https://doaj.org/toc/1809-452X |
| DOI: | 10.1590/1516-4446-2019-0803 |
| URL الوصول: | https://doaj.org/article/19b4e1f5205f442782987619e348bade |
| رقم الأكسشن: | edsdoj.19b4e1f5205f442782987619e348bade |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1809452X 15164446 |
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| DOI: | 10.1590/1516-4446-2019-0803 |