دورية أكاديمية

Association of mast cells with lung function in chronic obstructive pulmonary disease

التفاصيل البيبلوغرافية
العنوان: Association of mast cells with lung function in chronic obstructive pulmonary disease
المؤلفون: Luinge Marjan A, Smith Mieke, Lodewijk Monique, Rutgers Bea, Vonk Judith M, Postma Dirkje S, Gosman Margot ME, ten Hacken Nick HT, Timens Wim
المصدر: Respiratory Research, Vol 9, Iss 1, p 64 (2008)
بيانات النشر: BMC, 2008.
سنة النشر: 2008
المجموعة: LCC:Diseases of the respiratory system
مصطلحات موضوعية: Diseases of the respiratory system, RC705-779
الوصف: Abstract Background In asthma, higher chymase positive mast cell (MC-C) numbers are associated with less airway obstruction. In COPD, the distribution of MC-C and tryptase positive mast cells (MC-T) in central and peripheral airways, and their relation with lung function, is unknown. We compared MC-T and MC-C distributions in COPD and controls without airflow limitation, and determined their relation with lung function. Methods Lung tissue sections from 19 COPD patients (median [interquartile range] FEV1% predicted 56 [23–75]) and 10 controls were stained for tryptase and chymase. Numbers of MC-T and MC-C were determined in different regions of central and peripheral airways and percentage of degranulation was determined. Results COPD patients had lower MC-T numbers in the subepithelial area of central airways than controls. In COPD, MC-T numbers in the airway wall and more specifically in the epithelium and subepithelial area of peripheral airways correlated positively with FEV1/VC (Spearman's rho (rs) 0.47, p = 0.05 and rs 0.48, p = 0.05, respectively); MC-C numbers in airway smooth muscle of peripheral airways correlated positively with FEV1% predicted (rs 0.57, p = 0.02). Both in COPD patients and controls the percentage of degranulated MC-T and MC-C mast cells was higher in peripheral than in central airways (all p < 0.05), but this was not different between the groups. Conclusion More MC-T and MC-C in peripheral airways correlate with better lung function in COPD patients. It is yet to determine whether this reflects a protective association of mast cells with COPD pathogenesis, or that other explanations are to be considered.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1465-9921
Relation: http://respiratory-research.com/content/9/1/64; https://doaj.org/toc/1465-9921
DOI: 10.1186/1465-9921-9-64
URL الوصول: https://doaj.org/article/e19ffb96b97c475391103f40b2491ce5
رقم الأكسشن: edsdoj.19ffb96b97c475391103f40b2491ce5
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14659921
DOI:10.1186/1465-9921-9-64