دورية أكاديمية

Short-term long chain omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice.

التفاصيل البيبلوغرافية
العنوان: Short-term long chain omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice.
المؤلفون: Virginie F Labrousse, Agnès Nadjar, Corinne Joffre, Laurence Costes, Agnès Aubert, Stéphane Grégoire, Lionel Bretillon, Sophie Layé
المصدر: PLoS ONE, Vol 7, Iss 5, p e36861 (2012)
بيانات النشر: Public Library of Science (PLoS), 2012.
سنة النشر: 2012
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Regular consumption of food enriched in omega3 polyunsaturated fatty acids (ω3 PUFAs) has been shown to reduce risk of cognitive decline in elderly, and possibly development of Alzheimer's disease. Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are the most likely active components of ω3-rich PUFAs diets in the brain. We therefore hypothesized that exposing mice to a DHA and EPA enriched diet may reduce neuroinflammation and protect against memory impairment in aged mice. For this purpose, mice were exposed to a control diet throughout life and were further submitted to a diet enriched in EPA and DHA during 2 additional months. Cytokine expression together with a thorough analysis of astrocytes morphology assessed by a 3D reconstruction was measured in the hippocampus of young (3-month-old) and aged (22-month-old) mice. In addition, the effects of EPA and DHA on spatial memory and associated Fos activation in the hippocampus were assessed. We showed that a 2-month EPA/DHA treatment increased these long-chain ω3 PUFAs in the brain, prevented cytokines expression and astrocytes morphology changes in the hippocampus and restored spatial memory deficits and Fos-associated activation in the hippocampus of aged mice. Collectively, these data indicated that diet-induced accumulation of EPA and DHA in the brain protects against neuroinflammation and cognitive impairment linked to aging, further reinforcing the idea that increased EPA and DHA intake may provide protection to the brain of aged subjects.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC3360741?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0036861
URL الوصول: https://doaj.org/article/1a01484e22cb42b09e302a1eae572577
رقم الأكسشن: edsdoj.1a01484e22cb42b09e302a1eae572577
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0036861