دورية أكاديمية
Immunohistochemical expression of Cyclin D1 among Sudanese patients diagnosed with benign and malignant prostatic lesions
| العنوان: | Immunohistochemical expression of Cyclin D1 among Sudanese patients diagnosed with benign and malignant prostatic lesions |
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| المؤلفون: | Eiman Siddig Ahmed, Lubna S. Elnour, Rowa Hassan, Emmanuel E. Siddig, Mintu Elsa Chacko, Eman T. Ali, Mona A. Mohamed, Abdalla Munir, Mohamed S. Muneer, Nouh S. Mohamed, Ali M. M. Edris |
| المصدر: | BMC Research Notes, Vol 13, Iss 1, Pp 1-6 (2020) |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine LCC:Biology (General) LCC:Science (General) |
| مصطلحات موضوعية: | Prostate cancer, Immunohistochemical expression, Prognostic markers, Cyclin D1, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390 |
| الوصف: | Abstract Objectives Prostate cancer (PC) is common cancer worldwide. Several markers have been developed to differentiate between benign prostatic hyperplasia (BPH) from PC. A descriptive retrospective hospital-based study aimed at determining the expression of Cyclin D1 in BPH and PC. The study took place at different histopathology laboratories in Khartoum state, Sudan, from December 2016 to January 2019. Formalin-fixed paraffin-embedded blocks were sectioned and fixed in 3-aminopropyltriethoxysilane coated slides incubated into primary antibody for Cyclin D1. The assessment of immunoreactivity of Cyclin D1 of each section was done using the Gleason scoring system. Results A total of 153 males’ prostate sections included in this study, of them, 120 (78.4%) were PC, and 33 (21.6%) were BPH. Their age ranged from 45 to 88 years, mean age was 66.19 ± 8.599. 142 (92.8%) did not have a family history of PC, while 11 (7.2%) patients reported having a family history. The Gleason scoring showed a total of 81 (52.9%) patients with high-grade and 39 (25.5%) with low-grade. 118 (97.5%) patients had PC showed positive results for Cyclin D1, while BPH was 3 (2.5%). P value |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1756-0500 |
| Relation: | http://link.springer.com/article/10.1186/s13104-020-05138-7; https://doaj.org/toc/1756-0500 |
| DOI: | 10.1186/s13104-020-05138-7 |
| URL الوصول: | https://doaj.org/article/1a1670b875bf4ff9bf9a541d600d7f04 |
| رقم الأكسشن: | edsdoj.1a1670b875bf4ff9bf9a541d600d7f04 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 17560500 |
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| DOI: | 10.1186/s13104-020-05138-7 |