دورية أكاديمية
Comparison of Pain Relief from Different Intravenous Doses of Ketorolac after Reduction of Mandibular Fractures
| العنوان: | Comparison of Pain Relief from Different Intravenous Doses of Ketorolac after Reduction of Mandibular Fractures |
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| المؤلفون: | Saeed Nezafati, Reza Khorshidi Khiavi, Seyyed Sina Mirinejhad, Dawood Aghamoh Ammadi, Milad Ghanizadeh |
| المصدر: | Journal of Clinical and Diagnostic Research, Vol 11, Iss 9, Pp PC06-PC10 (2017) |
| بيانات النشر: | JCDR Research and Publications Private Limited, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | nonsteroidal anti-inflammatory drugs, opioid, postoperative pain, Medicine |
| الوصف: | Introduction: Pain is an unpleasant feeling due to tissue destruction, which disturbs an individual’s daily routines even at its lowest levels. The majority of surgeons and anaesthesiologists are increasingly trying to administer non-opioid analgesics because excessive use of opioids after surgery results in patient dissatisfaction. Aim: To evaluate the analgesic effect of intravenous injection of different doses of ketorolac at different intervals in patients undergoing surgery for unilateral fractures of the mandible. Materials and Methods: In the present randomized clinical trial (March 2016 to January 2017, in Tabriz Imam Reza Treatment/ Educational Center), 50 patients were assigned to five groups with simple randomization method. In Group 1 and 2, immediately before the induction of general anaesthesia 30 and 60 mg of ketorolac and in Group 3 and 4, immediately before termination of surgery 30 and 60 mg of ketorolac was injected intravenously. In Group 5, ketorolac was not administered. After each patient regained complete consciousness, the severity of pain was determined using VAS up to 24 hours at baseline and at 2, 4, 6, 12 and 24-hours intervals. The total dose of the opioid analgesic agent (morphine-pethidine) and the time for the first request for an analgesic agent were recorded for each patient and their means were compared in each group with suitable statistical tests. Results: The patients in Group 5 and 4 exhibited the highest and lowest mean pain scores (5.03±0.9 and 3.5±1), respectively. ANOVA for repeated measures and post-hoc Tukey tests showed significant differences only between Group 3 and 5 (p=0.002) and Group 4 and 5 (p=0.001), with no significant differences between the other groups (p>0.005). The highest dose of the analgesic agent was in Group 5 (5.3±1.4 mg) and the lowest dose was recorded in Group 4 (1.6±0.6 mg). Patients in the control group received significantly higher doses compared to the other groups (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2249-782X 0973-709X |
| Relation: | https://jcdr.net/articles/PDF/10558/30946_CE(RA1)_F(T)_PF1[NE_VT_AP]_PFA(SY_GG).pdf; https://doaj.org/toc/2249-782X; https://doaj.org/toc/0973-709X |
| DOI: | 10.7860/JCDR/2017/30946.10558 |
| URL الوصول: | https://doaj.org/article/1a1f4fa44cfa4f9a9a60f8b5ee29f3d0 |
| رقم الأكسشن: | edsdoj.1a1f4fa44cfa4f9a9a60f8b5ee29f3d0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2249782X 0973709X |
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| DOI: | 10.7860/JCDR/2017/30946.10558 |