دورية أكاديمية
Analysis of the genetic basis of height in large Jewish nuclear families.
| العنوان: | Analysis of the genetic basis of height in large Jewish nuclear families. |
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| المؤلفون: | Danny Zeevi, Joshua S Bloom, Meru J Sadhu, Adi Ben Yehuda, David Zangen, Ephrat Levy-Lahad, Leonid Kruglyak |
| المصدر: | PLoS Genetics, Vol 15, Iss 7, p e1008082 (2019) |
| بيانات النشر: | Public Library of Science (PLoS), 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Genetics |
| مصطلحات موضوعية: | Genetics, QH426-470 |
| الوصف: | Despite intensive study, most of the specific genetic factors that contribute to variation in human height remain undiscovered. We conducted a family-based linkage study of height in a unique cohort of very large nuclear families from a founder (Jewish) population. This design allowed for increased power to detect linkage, compared to previous family-based studies. Loci we identified in discovery families could explain an estimated lower bound of 6% of the variance in height in validation families. We showed that these loci are not tagging known common variants associated with height. Rather, we suggest that the observed signals arise from variants with large effects that are rare globally but elevated in frequency in the Jewish population. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1553-7390 1553-7404 |
| Relation: | https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404 |
| DOI: | 10.1371/journal.pgen.1008082 |
| URL الوصول: | https://doaj.org/article/c1a329b34f5449f6ae4eb14a9a42c740 |
| رقم الأكسشن: | edsdoj.1a329b34f5449f6ae4eb14a9a42c740 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15537390 15537404 |
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| DOI: | 10.1371/journal.pgen.1008082 |