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Inflammatory, Serological and Vascular Determinants of Cardiovascular Disease in Systemic Lupus Erythematosus Patients

التفاصيل البيبلوغرافية
العنوان: Inflammatory, Serological and Vascular Determinants of Cardiovascular Disease in Systemic Lupus Erythematosus Patients
المؤلفون: Valentina Mercurio, Antonio Lobasso, Letizia Barbieri, Paolo Parrella, Deasy Ciervo, Bianca Liccardo, Domenico Bonaduce, Carlo G. Tocchetti, Amato De Paulis, Francesca W. Rossi
المصدر: International Journal of Molecular Sciences, Vol 20, Iss 9, p 2154 (2019)
بيانات النشر: MDPI AG, 2019.
سنة النشر: 2019
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: cardiovascular disease, systemic lupus erythematosus, inflammation, arterial stiffness, augmentation index, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Background and aim: Systemic lupus erythematosus (SLE) is associated with increased risk of cardiovascular disease (CVD). Among many mechanisms, accelerated atherosclerosis, endothelial dysfunction, and hypercoagulability play a main role. Here, we investigate whether inflammatory, serological and clinical markers of SLE determine and correlate with arterial stiffness in SLE patients. Materials and methods: Routine blood samples, inflammatory mediators, specific antibodies, and 24 h proteinuria were measured in 43 SLE patients and 43 age and sex-matched controls using routine laboratory assays. We also assessed arterial stiffness by measuring radial artery applanation tonometry-derived augmentation index (AI), normalized AI (AIx@75), aortic pulse pressure, central systolic, diastolic and peripheral blood pressure. Results: SLE patients showed a significantly greater arterial stiffness vs. controls, as demonstrated by the significantly higher AIx@75 and aortic pulse pressure. Interestingly, regression analysis showed that age, systolic pulse pressure, inflammatory markers (erythrocyte sedimentation rate and C-reactive protein), daily dose of glucocorticoids, and cumulative organ damage positively correlated with arterial stiffness. Conclusions: SLE patients show increased arterial stiffness which correlates with markers of inflammation, that is involved in early alterations in arterial walls. Applanation tonometry can be used to screen SLE patients for subclinical vascular damage to implement prevention strategies for CVD.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
Relation: https://www.mdpi.com/1422-0067/20/9/2154; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms20092154
URL الوصول: https://doaj.org/article/1a5be8bdd34a4d8eb20e6b205cb282bf
رقم الأكسشن: edsdoj.1a5be8bdd34a4d8eb20e6b205cb282bf
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
DOI:10.3390/ijms20092154