دورية أكاديمية
Inhibition of Hedgehog Delays Liver Regeneration through Disrupting the Cell Cycle
| العنوان: | Inhibition of Hedgehog Delays Liver Regeneration through Disrupting the Cell Cycle |
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| المؤلفون: | Jiawang Tao, Yan Chen, Yuanqi Zhuang, Ruzhi Wei, Anteneh Getachew, Tingcai Pan, Fan Yang, Yinxiong Li |
| المصدر: | Current Issues in Molecular Biology, Vol 44, Iss 2, Pp 470-482 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | vismodegib, smoothened, liver regeneration, hedgehog signaling, mitosis, Biology (General), QH301-705.5 |
| الوصف: | Liver regeneration is a complicated biological process orchestrated by various liver resident cells. Hepatic cell proliferation and reconstruction of the hepatic architecture involve multiple signaling pathways. It has been reported that the Hh signal is involved in liver regeneration. However, the signal transduction pathways and cell types involved are ill studied. This study aimed to investigate hedgehog signal response cell types and the specific molecular mechanism involved in the process of liver regeneration. Partial hepatectomy (PH) of 70% was performed on ICR (Institute of Cancer Research) mice to study the process of liver regeneration. We found that the hedgehog signal was activated significantly after PH, including hedgehog ligands, receptors and intracellular signaling molecules. Ligand signals were mainly expressed in bile duct cells and non-parenchymal hepatic cells, while receptors were expressed in hepatocytes and some non-parenchymal cells. Inhibition of the hedgehog signal treated with vismodegib reduced the liver regeneration rate after partial hepatectomy, including inhibition of hepatic cell proliferation by decreasing Cyclin D expression and disturbing the cell cycle through the accumulation of Cyclin B. The current study reveals the important role of the hedgehog signal and its participation in the regulation of hepatic cell proliferation and the cell cycle during liver regeneration. It provides new insight into the recovery of the liver after liver resection. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1467-3045 1467-3037 |
| Relation: | https://www.mdpi.com/1467-3045/44/2/32; https://doaj.org/toc/1467-3037; https://doaj.org/toc/1467-3045 |
| DOI: | 10.3390/cimb44020032 |
| URL الوصول: | https://doaj.org/article/1a61d53a5a2b4f93ba87dcedb631a156 |
| رقم الأكسشن: | edsdoj.1a61d53a5a2b4f93ba87dcedb631a156 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14673045 14673037 |
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| DOI: | 10.3390/cimb44020032 |