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Diagnostic and predictive values of circulating tetrahydrobiopterin levels as a novel biomarker in patients with thoracic and abdominal aortic aneurysms

التفاصيل البيبلوغرافية
العنوان: Diagnostic and predictive values of circulating tetrahydrobiopterin levels as a novel biomarker in patients with thoracic and abdominal aortic aneurysms
المؤلفون: Yixuan Zhang, Kin Lung Siu, Qiang Li, Kimberly Howard-Quijano, Jennifer Scovotti, Aman Mahajan, Hua Cai
المصدر: Redox Biology, Vol 56, Iss , Pp 102444- (2022)
بيانات النشر: Elsevier, 2022.
سنة النشر: 2022
المجموعة: LCC:Medicine (General)
LCC:Biology (General)
مصطلحات موضوعية: Aortic aneurysm, Thoracic aortic aneurysm (TAA), Abdominal aortic aneurysm (AAA), Tetrahydrobiopterin (H4B), eNOS uncoupling, Human patients, Medicine (General), R5-920, Biology (General), QH301-705.5
الوصف: We have previously shown that circulating levels of tetrahydrobiopterin (H4B) function as a robust biomarker for aortic aneurysms in several independent animal models. In the present study, we examined diagnostic and predictive values of circulating H4B levels in human patients of thoracic aortic aneurysm (TAA) and abdominal aortic aneurysm (AAA) for the first time, while clinically applicable biomarkers for aortic aneurysms have never been previously available. Ninety-five patients scheduled for TAA repair surgeries and 53 control subjects were recruited at University of California Los Angeles (UCLA) Ronald Regan Medical Center, while 44 control subjects and 29 AAA patients were recruited through National Institute of Health (NIH) National Disease Research Interchange (NDRI) program. We had intriguing observations that circulating H4B levels were substantially lower in TAA and AAA patients, linearly correlated with aortic H4B levels (blood: R = 0.8071, p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2213-2317
Relation: http://www.sciencedirect.com/science/article/pii/S2213231722002166; https://doaj.org/toc/2213-2317
DOI: 10.1016/j.redox.2022.102444
URL الوصول: https://doaj.org/article/dc1a9b0c07ef49d39d7a042e70431baf
رقم الأكسشن: edsdoj.1a9b0c07ef49d39d7a042e70431baf
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:22132317
DOI:10.1016/j.redox.2022.102444