دورية أكاديمية
The role of cholesterol-enriched diet and paraoxonase 1 inhibition in atherosclerosis progression
| العنوان: | The role of cholesterol-enriched diet and paraoxonase 1 inhibition in atherosclerosis progression |
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| المؤلفون: | Masoumeh Amani, Akbar Darbin, Masoud Pezeshkian, Abbas Afrasiabi, Naser Safaie, Ahmadreza Jodati, Masoud Darabi, Maghsod Shaaker, Zeinab Latifi, Amir Fattahi, Gholam-Hossein Farjah, Mohammad Nouri, Mohammad Hassan Khadem-Ansari |
| المصدر: | Journal of Cardiovascular and Thoracic Research, Vol 9, Iss 3, Pp 133-139 (2017) |
| بيانات النشر: | Tabriz University of Medical Sciences, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | Atherosclerosis, Atheroma, Paraoxonase1, Nandrolone Decanoate, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Introduction: Atherosclerosis could be deemed as a chronic, progressive, and inflammatory disease. It has been well-documented that high-density lipoprotein (HDL) can reduce the risk of the atherosclerosis occurrence through exerting some anti-atherogenic mechanisms. In recent years, the strong evidence has suggested that paraoxonase 1 (PON1) may contribute to antioxidant properties of HDL. In the present study, the impact of a diet enriched with cholesterol and also the PON1 inhibition on atheroma formation and lipid profile has been investigated. Methods: In this study, 24 New Zealand rabbits were randomly assigned to three groups receiving standard diet, atherogenic diet, and atherogenic diet plus once daily intramuscular injection of nandrolone decanoate as the PON1 inhibitor. Triglyceride, cholesterol, HDL, and low-density lipoprotein (LDL) were determined and both cholesterol accumulation in aorta and fatty streak formation were evaluated. Results: The comparison of the results in three groups reveals that cholesterol level in the group received cholesterol-enriched diet plus once daily injection of PON1 inhibitor was higher than the groups received standard diet or atherogenic diet without PON1 inhibitor (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2008-5117 2008-6830 |
| Relation: | http://jcvtr.tbzmed.ac.ir/PDF/JCVTR-9-133.pdf; https://doaj.org/toc/2008-5117; https://doaj.org/toc/2008-6830 |
| DOI: | 10.15171/jcvtr.2017.23 |
| URL الوصول: | https://doaj.org/article/1b26b0e734b94318a43b3b197639e171 |
| رقم الأكسشن: | edsdoj.1b26b0e734b94318a43b3b197639e171 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20085117 20086830 |
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| DOI: | 10.15171/jcvtr.2017.23 |