دورية أكاديمية
Programmable ultrasound imaging guided theranostic nanodroplet destruction for precision therapy of breast cancer
| العنوان: | Programmable ultrasound imaging guided theranostic nanodroplet destruction for precision therapy of breast cancer |
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| المؤلفون: | Feihong Dong, Jian An, Wenyu Guo, Jie Dang, Shuo Huang, Feng Feng, Jiabin Zhang, Di Wang, Jingyi Yin, Jing Fang, Heping Cheng, Jue Zhang |
| المصدر: | Ultrasonics Sonochemistry, Vol 105, Iss , Pp 106854- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Chemistry LCC:Acoustics. Sound |
| مصطلحات موضوعية: | Spontaneous Nucleation, DOX-Loaded Nanodroplets, Programmable Ultrasound Imaging, Acoustic Droplet Vaporization, Precision Therapy, Chemistry, QD1-999, Acoustics. Sound, QC221-246 |
| الوصف: | Ultrasound-stimulated contrast agents have gained significant attention in the field of tumor treatment as drug delivery systems. However, their limited drug-loading efficiency and the issue of bulky, imprecise release have resulted in inadequate drug concentrations at targeted tissues. Herein, we developed a highly efficient approach for doxorubicin (DOX) precise release at tumor site and real-time feedback via an integrated strategy of “programmable ultrasonic imaging guided accurate nanodroplet destruction for drug release” (PND). We synthesized DOX-loaded nanodroplets (DOX-NDs) with improved loading efficiency (15 %) and smaller size (mean particle size: 358 nm). These DOX-NDs exhibited lower ultrasound activation thresholds (2.46 MPa). By utilizing a single diagnostic transducer for both ultrasound stimulation and imaging guidance, we successfully vaporized the DOX-NDs and released the drug at the tumor site in 4 T1 tumor-bearing mice. Remarkably, the PND group achieved similar tumor remission effects with less than half the dose of DOX required in conventional treatment. Furthermore, the ultrasound-mediated vaporization of DOX-NDs induced tumor cell apoptosis with minimal damage to surrounding normal tissues. In summary, our PND strategy offers a precise and programmable approach for drug delivery and therapy, combining ultrasound imaging guidance. This approach shows great potential in enhancing tumor treatment efficacy while minimizing harm to healthy tissues. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1350-4177 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1350417724001020; https://doaj.org/toc/1350-4177 |
| DOI: | 10.1016/j.ultsonch.2024.106854 |
| URL الوصول: | https://doaj.org/article/1b6916c4dcb149c793df1ebe1d0dd208 |
| رقم الأكسشن: | edsdoj.1b6916c4dcb149c793df1ebe1d0dd208 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13504177 |
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| DOI: | 10.1016/j.ultsonch.2024.106854 |