دورية أكاديمية
Association of 370-371insACA, 494T>C, and 1423C>T haplotype in ubiquitin-specific protease 26 gene and male infertility: a meta-analysis
| العنوان: | Association of 370-371insACA, 494T>C, and 1423C>T haplotype in ubiquitin-specific protease 26 gene and male infertility: a meta-analysis |
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| المؤلفون: | Jia-Dong Xia, Jie Chen, You-Feng Han, Hai Chen, Wen Yu, Yun Chen, Yu-Tian Dai |
| المصدر: | Asian Journal of Andrology, Vol 16, Iss 5, Pp 720-724 (2014) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Diseases of the genitourinary system. Urology |
| مصطلحات موضوعية: | haplotype, male infertility, meta-analysis, ubiquitin-specific protease 26, Diseases of the genitourinary system. Urology, RC870-923 |
| الوصف: | Whether the 370-371insACA, 494T>C, and 1423C>T haplotype in ubiquitin-specific protease 26 (USP26) gene is associated with male infertility is controversial. To clarify this issue, we conducted a meta-analysis based on the most recent studies. Eligible studies were screened by using PubMed and Embase. Pooled odd ratio (OR) with 95% confidence interval (CI) was calculated with fixed effect models. Ten studies with 1603 patients and 2505 controls were included. Overall, the results indicated that there was an association between the haplotype and male infertile risk (OR = 1.74, 95% CI: 1.09-2.77). The OR calculated based on the five studies in Asia and three in Europe was 1.96 (95% CI: 1.05-3.67) and 1.54 (95% CI: 0.75-3.16) respectively, however, the OR was 0.86 (95% CI: 0.05-15.29) based on the two investigations in America. In addition, the data from the patients with azoospermia (AZO) showed an increased pooled OR of 2.35 (95% CI: 1.22-4.50). In contrast, the studies with oligoasthenoteratozoospermia (OAT) exhibited that the pooled OR was 0.97 (95% CI: 0.43-2.16). Our analyses indicate that there is an association of alteration in USP26 with male infertility, especially in AZO and Asian population. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1008-682X 1745-7262 |
| Relation: | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=5;spage=720;epage=724;aulast=Xia; https://doaj.org/toc/1008-682X; https://doaj.org/toc/1745-7262 |
| DOI: | 10.4103/1008-682X.129134 |
| URL الوصول: | https://doaj.org/article/cee1b6aa42754b219332cc2051a2733e |
| رقم الأكسشن: | edsdoj.1b6aa42754b219332cc2051a2733e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1008682X 17457262 |
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| DOI: | 10.4103/1008-682X.129134 |