دورية أكاديمية
Low back pain and osteoarthritis pain: a perspective of estrogen
| العنوان: | Low back pain and osteoarthritis pain: a perspective of estrogen |
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| المؤلفون: | Huiwen Pang, Shihui Chen, David M. Klyne, David Harrich, Wenyuan Ding, Sidong Yang, Felicity Y. Han |
| المصدر: | Bone Research, Vol 11, Iss 1, Pp 1-14 (2023) |
| بيانات النشر: | Nature Publishing Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) LCC:Physiology |
| مصطلحات موضوعية: | Biology (General), QH301-705.5, Physiology, QP1-981 |
| الوصف: | Abstract Low back pain (LBP) is the world’s leading cause of disability and is increasing in prevalence more rapidly than any other pain condition. Intervertebral disc (IVD) degeneration and facet joint osteoarthritis (FJOA) are two common causes of LBP, and both occur more frequently in elderly women than in other populations. Moreover, osteoarthritis (OA) and OA pain, regardless of the joint, are experienced by up to twice as many women as men, and this difference is amplified during menopause. Changes in estrogen may be an important contributor to these pain states. Receptors for estrogen have been found within IVD tissue and nearby joints, highlighting the potential roles of estrogen within and surrounding the IVDs and joints. In addition, estrogen supplementation has been shown to be effective at ameliorating IVD degeneration and OA progression, indicating its potential use as a therapeutic agent for people with LBP and OA pain. This review comprehensively examines the relationship between estrogen and these pain conditions by summarizing recent preclinical and clinical findings. The potential molecular mechanisms by which estrogen may relieve LBP associated with IVD degeneration and FJOA and OA pain are discussed. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2095-6231 |
| Relation: | https://doaj.org/toc/2095-6231 |
| DOI: | 10.1038/s41413-023-00280-x |
| URL الوصول: | https://doaj.org/article/1b7cddcba8ad478496a532d2c64eb687 |
| رقم الأكسشن: | edsdoj.1b7cddcba8ad478496a532d2c64eb687 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20956231 |
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| DOI: | 10.1038/s41413-023-00280-x |