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Neuroimaging abnormalities associated with immunotherapy responsiveness in Down syndrome regression disorder

التفاصيل البيبلوغرافية
العنوان: Neuroimaging abnormalities associated with immunotherapy responsiveness in Down syndrome regression disorder
المؤلفون: Jonathan D. Santoro, Mellad M. Khoshnood, Saba Jafarpour, Lina Nguyen, Natalie K. Boyd, Benjamin N. Vogel, Ryan Kammeyer, Lina Patel, Melanie A. Manning, Angela L. Rachubinski, Robyn A. Filipink, Nicole T. Baumer, Stephanie L. Santoro, Catherine Franklin, Benita Tamrazi, Kristen W. Yeom, Gordon Worley, Joaquin M. Espinosa, Michael S. Rafii
المصدر: Annals of Clinical and Translational Neurology, Vol 11, Iss 4, Pp 1034-1045 (2024)
بيانات النشر: Wiley, 2024.
سنة النشر: 2024
المجموعة: LCC:Neurosciences. Biological psychiatry. Neuropsychiatry
LCC:Neurology. Diseases of the nervous system
مصطلحات موضوعية: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
الوصف: Abstract Objective To determine the prevalence of neuroimaging abnormalities in individuals with Down syndrome regression disorder (DSRD) and evaluate if neuroimaging abnormalities were predictive of therapeutic responses. Methods A multicenter, retrospective, case–control study which reviewed neuroimaging studies of individuals with DSRD and compared them to a control cohort of individuals with Down syndrome (DS) alone was performed. Individuals aged 10–30 years and meeting international consensus criteria for DSRD were included. The presence of T1, T2/FLAIR, and SWI signal abnormalities was reviewed. Response rates to various therapies, including immunotherapy, were evaluated in the presence of neuroimaging abnormalities. Results In total, 74 individuals (35%) had either T2/FLAIR and/or SWI signal abnormality compared to 14 individuals (12%) without DSRD (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2328-9503
Relation: https://doaj.org/toc/2328-9503
DOI: 10.1002/acn3.52023
URL الوصول: https://doaj.org/article/1b84b6540fc14bc19651701e6c60b706
رقم الأكسشن: edsdoj.1b84b6540fc14bc19651701e6c60b706
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23289503
DOI:10.1002/acn3.52023