دورية أكاديمية
Neuroimaging abnormalities associated with immunotherapy responsiveness in Down syndrome regression disorder
العنوان: | Neuroimaging abnormalities associated with immunotherapy responsiveness in Down syndrome regression disorder |
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المؤلفون: | Jonathan D. Santoro, Mellad M. Khoshnood, Saba Jafarpour, Lina Nguyen, Natalie K. Boyd, Benjamin N. Vogel, Ryan Kammeyer, Lina Patel, Melanie A. Manning, Angela L. Rachubinski, Robyn A. Filipink, Nicole T. Baumer, Stephanie L. Santoro, Catherine Franklin, Benita Tamrazi, Kristen W. Yeom, Gordon Worley, Joaquin M. Espinosa, Michael S. Rafii |
المصدر: | Annals of Clinical and Translational Neurology, Vol 11, Iss 4, Pp 1034-1045 (2024) |
بيانات النشر: | Wiley, 2024. |
سنة النشر: | 2024 |
المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry LCC:Neurology. Diseases of the nervous system |
مصطلحات موضوعية: | Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429 |
الوصف: | Abstract Objective To determine the prevalence of neuroimaging abnormalities in individuals with Down syndrome regression disorder (DSRD) and evaluate if neuroimaging abnormalities were predictive of therapeutic responses. Methods A multicenter, retrospective, case–control study which reviewed neuroimaging studies of individuals with DSRD and compared them to a control cohort of individuals with Down syndrome (DS) alone was performed. Individuals aged 10–30 years and meeting international consensus criteria for DSRD were included. The presence of T1, T2/FLAIR, and SWI signal abnormalities was reviewed. Response rates to various therapies, including immunotherapy, were evaluated in the presence of neuroimaging abnormalities. Results In total, 74 individuals (35%) had either T2/FLAIR and/or SWI signal abnormality compared to 14 individuals (12%) without DSRD (p |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2328-9503 |
Relation: | https://doaj.org/toc/2328-9503 |
DOI: | 10.1002/acn3.52023 |
URL الوصول: | https://doaj.org/article/1b84b6540fc14bc19651701e6c60b706 |
رقم الأكسشن: | edsdoj.1b84b6540fc14bc19651701e6c60b706 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 23289503 |
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DOI: | 10.1002/acn3.52023 |