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Preoperative smoking and robot-assisted radical cystectomy outcomes & complications in multicenter KORARC database

التفاصيل البيبلوغرافية
العنوان: Preoperative smoking and robot-assisted radical cystectomy outcomes & complications in multicenter KORARC database
المؤلفون: Joongwon Choi, Jooyoung Lee, Yu Been Hwang, Byong Chang Jeong, Sangchul Lee, Ja Hyeon Ku, Jong Kil Nam, Wansuk Kim, Ji Youl Lee, Sung Hoo Hong, Koon Ho Rha, Woong Kyu Han, Won Sik Ham, Sung Gu Kang, Seok Ho Kang, Jong Jin Oh, Young Goo Lee, Tae Gyun Kwon, Tae-Hwan Kim, Seung Hyun Jeon, Sang Hyub Lee, Sung Yul Park, Young Eun Yoon, Yong Seong Lee
المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
بيانات النشر: Nature Portfolio, 2024.
سنة النشر: 2024
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Bladder cancer, Smoking, Cystectomy, Survival analysis, Robot-assisted surgery, Medicine, Science
الوصف: Abstract To investigate the influence of preoperative smoking history on the survival outcomes and complications in a cohort from a large multicenter database. Many patients who undergo radical cystectomy (RC) have a history of smoking; however, the direct association between preoperative smoking history and survival outcomes and complications in patients with muscle-invasive bladder cancer (MIBC) who undergo robot-assisted radical cystectomy (RARC) remains unexplored. We conducted a retrospective analysis using data from 749 patients in the Korean Robot-Assisted Radical Cystectomy Study Group (KORARC) database, with an average follow-up duration of 30.8 months. The cohort was divided into two groups: smokers (n = 351) and non-smokers (n = 398). Propensity score matching was employed to address differences in sample size and baseline demographics between the two groups (n = 274, each). Comparative analyses included assessments of oncological outcomes and complications. After matching, smoking did not significantly affect the overall complication rate (p = 0.121). Preoperative smoking did not significantly increase the occurrence of complications based on complication type (p = 0.322), nor did it increase the readmission rate (p = 0.076). There were no perioperative death in either group. Furthermore, preoperative smoking history showed no significant impact on overall survival (OS) [hazard ratio (HR) = 0.87, interquartile range (IQR): 0.54–1.42; p = 0.589] and recurrence-free survival (RFS) (HR = 1.12, IQR: 0.83–1.53; p = 0.458) following RARC for MIBC. The extent of preoperative smoking (≤ 10, 10–30, and ≥ 30 pack-years) had no significant influence on OS and RFS in any of the categories (all p > 0.05). Preoperative smoking history did not significantly affect OS, RFS, or complications in patients with MIBC undergoing RARC.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-024-61005-6
URL الوصول: https://doaj.org/article/1ba2f92fa6c4470ea8f6c657f9c96564
رقم الأكسشن: edsdoj.1ba2f92fa6c4470ea8f6c657f9c96564
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-024-61005-6