دورية أكاديمية
Metastatic Lung Cancer to the Head and Neck: A Clinico-Pathological Study on 21 Cases with Narrative Review of the Literature
| العنوان: | Metastatic Lung Cancer to the Head and Neck: A Clinico-Pathological Study on 21 Cases with Narrative Review of the Literature |
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| المؤلفون: | Saverio Capodiferro, Antonio d’Amati, Giuseppe Barile, Fabio Dell’Olio, Luisa Limongelli, Angela Tempesta, Rosaria Arianna Siciliani, Giuseppe Ingravallo, Mauro Mastropasqua, Giuseppe Colella, Ciro Emiliano Boschetti, Chiara Copelli, Eugenio Maiorano, Gianfranco Favia |
| المصدر: | Journal of Clinical Medicine, Vol 12, Iss 4, p 1429 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | lung cancer, metastatic lung cancer, oral metastasis, head and neck metastasis, oral cavity, immunohistochemistry, Medicine |
| الوصف: | Metastases from lung cancer to the oral cavity and to the head and neck generally are very infrequent and usually manifest in advanced stages of the disease. Even more rarely, they are the first sign of an unknown metastatic disease. Nevertheless, their occurrence always represents a challenging situation both for clinicians, in the management of very unusual lesions, and for pathologists, in the recognition of the primary site. We retrospectively studied 21 cases of metastases to the head and neck from lung cancer (sixteen males and five females, age range 43–80 years; eight cases localized to the gingiva [two of these to the peri-implant gingiva], seven to the sub-mandibular lymph nodes, two to the mandible, three to the tongue, one case to the parotid gland; in eight patients, metastasis was the first clinical manifestation of an occult lung cancer) and proposed a wide immunohistochemical panel for a proper identification of the primary tumor histotype, including CK5/6, CK8/18, CK7, CK20, p40, p63, TTF-1, CDX2, Chromogranin A, Synaptophysin, GATA-3, Estrogen Receptors, PAX8, PSA. Furthermore, we collected data from previously published studies and narratively reviewed the relevant literature. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2077-0383 |
| Relation: | https://www.mdpi.com/2077-0383/12/4/1429; https://doaj.org/toc/2077-0383 |
| DOI: | 10.3390/jcm12041429 |
| URL الوصول: | https://doaj.org/article/1bb76699165141f3b2a988c4a68bd1eb |
| رقم الأكسشن: | edsdoj.1bb76699165141f3b2a988c4a68bd1eb |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20770383 |
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| DOI: | 10.3390/jcm12041429 |