دورية أكاديمية
The influence of pericentric inversion in 10th chromosome on aggressive behavior and hyperactivity
| العنوان: | The influence of pericentric inversion in 10th chromosome on aggressive behavior and hyperactivity |
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| المؤلفون: | Nilgun Tanriverdi, Ayfer Pazarbasi, Dilara Karahan, Ayse Avci, Aysegul Yolga Tahiroglu, Erdal Tunc, Osman Demirhan |
| المصدر: | Çukurova Üniversitesi Tıp Fakültesi Dergisi, Vol 38, Iss 1, Pp 108-113 (2013) |
| بيانات النشر: | Cukurova University, 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Medicine LCC:Medicine (General) |
| مصطلحات موضوعية: | Pericentric inversion, Chromosome 10p-q, Aggressive behavior, Hyperactivity, Mental retardation, Medicine, Medicine (General), R5-920 |
| الوصف: | Aggressive behavior and hyperactivity are neurodevelopmental diseases with unknown pathogenesis. Pericentric inv(10)(p11.2;q21.2) mutation is frequently encountered in cytogenetic laboratories. This mutation is accepted as a polymorphic variant and is phenotypically silent, but in some cases it has been associated with neurodevelopmental diseases like autism. After blood culturing, standard chromosome obtaining procedure was applied to patients. In this study, clinical and cytogenetical findings of a boy with developmental delay, mental and motor retardation, attention deficit and hyperactivity have been reported. As a result of chromosome analysis, on chromosome 10, a large pericentric inversion between p11.1 and q22.q bands has been found. Karyotype analysis was also performed to mother, father and siblings of the patient and they have been found to have normal karyotype. It is plausible to consider a relation between inv(10) and some behavioral problems. Additionally, molecular studies targeting 10p-q critical region will be more informative for the true identification of this disease. [Cukurova Med J 2013; 38(1.000): 108-113] |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Turkish |
| تدمد: | 0250-5150 |
| Relation: | http://www.scopemed.org/fulltextpdf.php?mno=26243; https://doaj.org/toc/0250-5150 |
| URL الوصول: | https://doaj.org/article/1c432abcc9974dfcb0286a04fa4e9e94 |
| رقم الأكسشن: | edsdoj.1c432abcc9974dfcb0286a04fa4e9e94 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 02505150 |
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