دورية أكاديمية
Differences between [18F]FLT and [18F]FDG Uptake in PET/CT Imaging in CC Depend on Vaginal Bacteriology
| العنوان: | Differences between [18F]FLT and [18F]FDG Uptake in PET/CT Imaging in CC Depend on Vaginal Bacteriology |
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| المؤلفون: | Ewa Burchardt, Zaneta Warenczak-Florczak, Paulina Cegła, Adam Piotrowski, Zefiryn Cybulski, Wojciech Burchardt, Andrzej Roszak, Witold Cholewiński |
| المصدر: | Diagnostics, Vol 12, Iss 1, p 70 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | 18F-fluorothymidine ([18F]FLT), 18F-fluoro-d-glucose ([18F]FDG), positron emission tomography computed tomography, vaginal bacteriology, cervical cancer, Medicine (General), R5-920 |
| الوصف: | This study aims to investigate if vaginal bacteriology obtained prior to treatment influences the 3′-deoxy-3 18F-fluorothymidine (FLT) [18F]FLT and 2-deoxy-2-[18F]fluoro-d-glucose (2-[18F]FDG) [18F]FDG parameters in positron emission tomography (PET/CT) in cervical cancer (CC) patients. Methods: Retrospective analysis was performed on 39 women with locally advanced histologically confirmed cervical cancer who underwent dual tracer PET/CT examinations. The [18F]FLT and [18F]FDG PET parameters in the primary tumor, including SUVmax, SUVmean, MTV, heterogeneity, before radiotherapy (RT) were analyzed, depending on the bacteriology. The p-values < 0.05 were considered statistically significant. Results: In the vaginal and/or cervical smears, there were 27 (79.4%) positive results. In seven (20.6%) cases, no opportunistic pathogen growth was observed (No Bacteria Group). In positive bacteriology, eleven (32%) Gram-negative bacilli (Bacteria group 2) and fifteen (44%) Gram-positive bacteria (Bacteria group 1) were detected. Five patients with unknown results were excluded from the analysis. Data analysis shows a statistically significant difference between the SUVmax, and SUVmin values for three independent groups for the [18F]FLT. Conclusions: The lowest values of SUVmax and SUVmin for [18F]FLT are registered in Gram-negative bacteria, higher are in Gram-positive, and the absence of bacteria causes the highest [18F]FLT values. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2075-4418 14360683 |
| Relation: | https://www.mdpi.com/2075-4418/12/1/70; https://doaj.org/toc/2075-4418 |
| DOI: | 10.3390/diagnostics12010070 |
| URL الوصول: | https://doaj.org/article/1cbfdb86e0494dcaa7b14360683d7cb8 |
| رقم الأكسشن: | edsdoj.1cbfdb86e0494dcaa7b14360683d7cb8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20754418 14360683 |
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| DOI: | 10.3390/diagnostics12010070 |