دورية أكاديمية

Sleep and cognition in aging dogs. A polysomnographic study

التفاصيل البيبلوغرافية
العنوان: Sleep and cognition in aging dogs. A polysomnographic study
المؤلفون: Alejandra Mondino, Magaly Catanzariti, Diego Martin Mateos, Michael Khan, Claire Ludwig, Anna Kis, Margaret E. Gruen, Natasha J. Olby
المصدر: Frontiers in Veterinary Science, Vol 10 (2023)
بيانات النشر: Frontiers Media S.A., 2023.
سنة النشر: 2023
المجموعة: LCC:Veterinary medicine
مصطلحات موضوعية: NREM sleep, REM sleep, canine cognitive dysfunction syndrome, quantitative EEG, power spectrum, coherence, Veterinary medicine, SF600-1100
الوصف: IntroductionSleep is fundamental for cognitive homeostasis, especially in senior populations since clearance of amyloid beta (key in the pathophysiology of Alzheimer's disease) occurs during sleep. Some electroencephalographic characteristics of sleep and wakefulness have been considered a hallmark of dementia. Owners of dogs with canine cognitive dysfunction syndrome (a canine analog to Alzheimer's disease) report that their dogs suffer from difficulty sleeping. The aim of this study was to quantify age-related changes in the sleep-wakefulness cycle macrostructure and electroencephalographic features in senior dogs and to correlate them with their cognitive performance.MethodsWe performed polysomnographic recordings in 28 senior dogs during a 2 h afternoon nap. Percentage of time spent in wakefulness, drowsiness, NREM, and REM sleep, as well as latency to the three sleep states were calculated. Spectral power, coherence, and Lempel Ziv Complexity of the brain oscillations were estimated. Finally, cognitive performance was evaluated by means of the Canine Dementia Scale Questionnaire and a battery of cognitive tests. Correlations between age, cognitive performance and sleep-wakefulness cycle macrostructure and electroencephalographic features were calculated.ResultsDogs with higher dementia scores and with worse performance in a problem-solving task spent less time in NREM and REM sleep. Additionally, quantitative electroencephalographic analyses showed differences in dogs associated with age or cognitive performance, some of them reflecting shallower sleep in more affected dogs.DiscussionPolysomnographic recordings in dogs can detect sleep-wakefulness cycle changes associated with dementia. Further studies should evaluate polysomnography's potential clinical use to monitor the progression of canine cognitive dysfunction syndrome.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2297-1769
Relation: https://www.frontiersin.org/articles/10.3389/fvets.2023.1151266/full; https://doaj.org/toc/2297-1769
DOI: 10.3389/fvets.2023.1151266
URL الوصول: https://doaj.org/article/c1d1c6a7838641b7b7ba4f6e5ea9476a
رقم الأكسشن: edsdoj.1d1c6a7838641b7b7ba4f6e5ea9476a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:22971769
DOI:10.3389/fvets.2023.1151266