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Relation between the frequency of CD34+ bone marrow derived circulating progenitor cells and the number of diseased coronary arteries in patients with myocardial ischemia and diabetes

التفاصيل البيبلوغرافية
العنوان: Relation between the frequency of CD34+ bone marrow derived circulating progenitor cells and the number of diseased coronary arteries in patients with myocardial ischemia and diabetes
المؤلفون: Bozdag-Turan Ilkay, Turan R Goekmen, Turan C Hakan, Ludovicy Sophie, Akin Ibrahim, Kische Stephan, Arsoy Nicole S, Schneider Henrik, Ortak Jasmin, Rehders Tim, Hermann Tina, Paranskaya Liliya, Kohlschein Peter, Bastian Manuela, Ulus A Tulga, Sahin Kurtulus, Ince Hueseyin, Nienaber Christoph A
المصدر: Cardiovascular Diabetology, Vol 10, Iss 1, p 107 (2011)
بيانات النشر: BMC, 2011.
سنة النشر: 2011
المجموعة: LCC:Diseases of the circulatory (Cardiovascular) system
مصطلحات موضوعية: CD34/45+, ischemic heart disease, diabetes, frequency, Diseases of the circulatory (Cardiovascular) system, RC666-701
الوصف: Abstract Background Bone marrow-derived circulating progenitor cells (BM-CPCs) in patients with coronary heart disease are impaired with respect to number and mobilization. However, it is unknown whether the mobilization of BM-CPCs depends on the number of diseased coronary arteries. Therefore, in our study, we analysed the correlation between the diseased coronary arteries and the frequency of CD34/45+ BM-CPCs in peripheral blood (PB) in patients with ischemic heart disease (IHD). Methods The frequency of CD34/45+ BM-CPCs was measured by flow cytometry in 120 patients with coronary 1 vessel (IHD1, n = 40), coronary 2 vessel (IHD2, n = 40), coronary 3 vessel disease (IHD3, n = 40) and in a control group of healthy subjects (n = 40). There was no significant difference of the total number of cardiovascular risk factors between IHD groups, beside diabetes mellitus (DM), which was significantly higher in IHD3 group compared to IHD2 and IHD1 groups. Results The frequency of CD34/45+ BM-CPCs was significantly reduced in patients with IHD compared to the control group (CD34/45+; p < 0.001). The frequency of BM-CPCs was impaired in patients with IHD3 compared to IHD1 (CD34/45+; p < 0.001) and to IHD2 (CD34/45+; p = 0.001). But there was no significant difference in frequency of BM-CPCs between the patients with IHD2 and IHD1 (CD34/45+; p = 0.28). In a subgroup we observed a significant negative correlation between levels of hemoglobin AIc (HbAIc) and the frequency of BM-CPCs (CD34/45+; p < 0.001, r = -0.8). Conclusions The frequency of CD34/45+ BM-CPCs in PB is impaired in patients with IHD. This impairment may augment with an increased number of diseased coronary arteries. Moreover, the frequency of CD34/45+ BM-CPCs in ischemic tissue is further impaired by diabetes in patients with IHD.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1475-2840
68506619
Relation: http://www.cardiab.com/content/10/1/107; https://doaj.org/toc/1475-2840
DOI: 10.1186/1475-2840-10-107
URL الوصول: https://doaj.org/article/1d29a8e9d69b4ffa80abb68506619ff3
رقم الأكسشن: edsdoj.1d29a8e9d69b4ffa80abb68506619ff3
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14752840
68506619
DOI:10.1186/1475-2840-10-107