دورية أكاديمية
Sarcopenia and bone health: new acquisitions for a firm liaison
| العنوان: | Sarcopenia and bone health: new acquisitions for a firm liaison |
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| المؤلفون: | Umberto Tarantino, Chiara Greggi, Virginia Veronica Visconti, Ida Cariati, Roberto Bonanni, Beatrice Gasperini, Italo Nardone, Elena Gasbarra, Riccardo Iundusi |
| المصدر: | Therapeutic Advances in Musculoskeletal Disease, Vol 14 (2022) |
| بيانات النشر: | SAGE Publishing, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Diseases of the musculoskeletal system |
| مصطلحات موضوعية: | Diseases of the musculoskeletal system, RC925-935 |
| الوصف: | Osteosarcopenia (OS) is a newly defined condition represented by the simultaneous presence of osteopenia/osteoporosis and sarcopenia, the main age-related diseases. The simultaneous coexistence of the two phenotypes derives from the close connection of the main target tissues involved in their pathogenesis: bone and muscle. These two actors constitute the bone–muscle unit, which communicates through a biochemical and mechanical crosstalk which involves multiple factors. Altered pattern of molecular pathways leads to an impairment of both the functionality of the tissue itself and the communication with the complementary tissue, composing the OS pathogenesis. Recent advances in the genetics field have provided the opportunity to delve deeper into the complex biological and molecular mechanisms underlying OS. Unfortunately, there are still many gaps in our understanding of these pathways, but it has proven essential to apply strategies such as exercise and nutritional intervention to counteract OS. New therapeutic strategies that simultaneously target bone and muscle tissue are limited, but recently new targets for the development of dual-action drug therapies have been identified. This narrative review aims to provide an overview of the latest scientific evidence associated with OS, a complex disorder that will pave the way for future research aimed at understanding the bone–muscle-associated pathogenetic mechanisms. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1759-7218 1759720X |
| Relation: | https://doaj.org/toc/1759-7218 |
| DOI: | 10.1177/1759720X221138354 |
| URL الوصول: | https://doaj.org/article/1d96fc291dab457da261f504e05ca944 |
| رقم الأكسشن: | edsdoj.1d96fc291dab457da261f504e05ca944 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17597218 1759720X |
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| DOI: | 10.1177/1759720X221138354 |