دورية أكاديمية
أعرض في EDS

NFIB Mediates BRN2 Driven Melanoma Cell Migration and Invasion Through Regulation of EZH2 and MITF

التفاصيل البيبلوغرافية
العنوان: NFIB Mediates BRN2 Driven Melanoma Cell Migration and Invasion Through Regulation of EZH2 and MITF
المؤلفون: Mitchell E. Fane, Yash Chhabra, David E.J. Hollingsworth, Jacinta L. Simmons, Loredana Spoerri, Tae Gyu Oh, Jagat Chauhan, Toby Chin, Lachlan Harris, Tracey J. Harvey, George E.O. Muscat, Colin R. Goding, Richard A Sturm, Nikolas K. Haass, Glen M. Boyle, Michael Piper, Aaron G. Smith
المصدر: EBioMedicine, Vol 16, Iss C, Pp 63-75 (2017)
بيانات النشر: Elsevier, 2017.
سنة النشر: 2017
المجموعة: LCC:Medicine
LCC:Medicine (General)
مصطلحات موضوعية: Melanoma, Metastasis, Invasion, BRN2, NFIB, Epigenetic, Medicine, Medicine (General), R5-920
الوصف: While invasion and metastasis of tumour cells are the principle factor responsible for cancer related deaths, the mechanisms governing the process remain poorly defined. Moreover, phenotypic divergence of sub-populations of tumour cells is known to underpin alternative behaviors linked to tumour progression such as proliferation, survival and invasion. In the context of melanoma, heterogeneity between two transcription factors, BRN2 and MITF, has been associated with phenotypic switching between predominantly invasive and proliferative behaviors respectively. Epigenetic changes, in response to external cues, have been proposed to underpin this process, however the mechanism by which the phenotypic switch occurs is unclear. Here we report the identification of the NFIB transcription factor as a novel downstream effector of BRN2 function in melanoma cells linked to the migratory and invasive characteristics of these cells. Furthermore, the function of NFIB appears to drive an invasive phenotype through an epigenetic mechanism achieved via the upregulation of the polycomb group protein EZH2. A notable target of NFIB mediated up-regulation of EZH2 is decreased MITF expression, which further promotes a less proliferative, more invasive phenotype. Together our data reveal that NFIB has the ability to promote dynamic changes in the chromatin state of melanoma cells to facilitate migration, invasion and metastasis.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2352-3964
Relation: http://www.sciencedirect.com/science/article/pii/S2352396417300178; https://doaj.org/toc/2352-3964
DOI: 10.1016/j.ebiom.2017.01.013
URL الوصول: https://doaj.org/article/1d9c7e7e95224d40a32f42bb4b0ce6d1
رقم الأكسشن: edsdoj.1d9c7e7e95224d40a32f42bb4b0ce6d1
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23523964
DOI:10.1016/j.ebiom.2017.01.013