A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes

التفاصيل البيبلوغرافية
العنوان:	A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes
المؤلفون:	Matthieu Dos Santos, Stéphanie Backer, Frédéric Auradé, Matthew Man-Kin Wong, Maud Wurmser, Rémi Pierre, Francina Langa, Marcio Do Cruzeiro, Alain Schmitt, Jean-Paul Concordet, Athanassia Sotiropoulos, F. Jeffrey Dilworth, Daan Noordermeer, Frédéric Relaix, Iori Sakakibara, Pascal Maire
المصدر:	Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
بيانات النشر:	Nature Portfolio, 2022.
سنة النشر:	2022
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	The contractile properties of adult myofibers are shaped by their Myosin heavy chain isoform content. Here the authors show that a super enhancer controls the spatiotemporal expression of the genes at the fast myosin heavy chain locus by DNA looping and that this expression profile is recapitulated in a rainbow transgenic mouse model of the locus.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-022-28666-1
URL الوصول:	https://doaj.org/article/1e1732b409944febbd7c8c1cfe87a24b
رقم الأكسشن:	edsdoj.1e1732b409944febbd7c8c1cfe87a24b
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-022-28666-1