دورية أكاديمية
Identification of Hsa_circ_0104824 as a Potential Biomarkers for Breast Cancer
| العنوان: | Identification of Hsa_circ_0104824 as a Potential Biomarkers for Breast Cancer |
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| المؤلفون: | Xiaohan Li MD, Fang Ma BA, Ligang Wu MD, Xu Zhang MD, Jinhai Tian MD, Jinping Li PhD, Jia Cao PhD, Yunfei Ma MD, Liang Zhang MD, Libin Wang PhD |
| المصدر: | Technology in Cancer Research & Treatment, Vol 19 (2020) |
| بيانات النشر: | SAGE Publishing, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Background: To study the specific expression of circular RNA (circRNA) in breast cancer and adjacent normal tissues to identify differentially expressed circRNA in breast cancer patients. To study the correlation between circRNA and clinical data of breast cancer, and to evaluate its potential as a breast cancer biomarker. Methods: The differential expression of circRNAs between the breast cancer tissues and adjacent normal tissues was screened by Human CircRNA Microarray. Candidate circRNAs verified by qRT-PCR. CircRNA was analyzed by Agilent GeneSpring 13.0 software. SPSS23.0, GraphPad Prism, and Sigmaplot software were used for statistical analysis. Perform T test, one-way ANOVA, curve regression analysis and ROC curve analysis for evaluating the diagnostic value of circular RNA. Results: Among the 2021 differentially expressed circRNAs, 546 were up-regulated and 1475 were down-regulated in breast cancer tissues. The validation study demonstrated that six circRNAs were downregulated. Among them, hsa_circ_0104824 proved high correlation between breast cancer tissues and plasma samples in its expression and diagnostic value. Conclusion: Hsa_circ_0104824 may serve as a promising predictive biomarker and therapeutic target for patients with breast cancer. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1533-0338 15330338 |
| Relation: | https://doaj.org/toc/1533-0338 |
| DOI: | 10.1177/1533033820960745 |
| URL الوصول: | https://doaj.org/article/1e1fff01b0474ba3bb45d118a7195822 |
| رقم الأكسشن: | edsdoj.1e1fff01b0474ba3bb45d118a7195822 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15330338 |
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| DOI: | 10.1177/1533033820960745 |