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Allicin affects immunoreactivity of osteosarcoma cells through lncRNA CBR3-AS1

التفاصيل البيبلوغرافية
العنوان: Allicin affects immunoreactivity of osteosarcoma cells through lncRNA CBR3-AS1
المؤلفون: Wenpeng Xie, Fengjun Ma, Luming Dou, Wenjie Chang, Daotong Yuan, Zhimeng Zhang, Yongkui Zhang
المصدر: Heliyon, Vol 10, Iss 11, Pp e31971- (2024)
بيانات النشر: Elsevier, 2024.
سنة النشر: 2024
المجموعة: LCC:Science (General)
LCC:Social sciences (General)
مصطلحات موضوعية: allicin, Osteosarcoma, lncRNA CBR3-AS1, miR-145-5p, GRP78, Immunological activity, Science (General), Q1-390, Social sciences (General), H1-99
الوصف: Objective: To analyze the effect of allicin on the immunoreactivity of osteosarcoma (OS) cells and further explore whether its mechanism is related to the long non-coding Ribonucleic Acid (lncRNA) CBR3-AS1/miR-145-5p/GRP78 axis, so as to provide clinical evidence. Methods: The human OS cell line Saos-2 was treated with allicin at 25, 50, and 100 μmol/L, respectively, to observe changes in cell biological behaviors. Subsequently, CBR3-AS1 abnormal expression vectors were constructed and transfected into Saos-2 to discuss their influence on OS. Furthermore, the regulatory relationship between allicin and the CBR3-AS1/miR-145-5p/GRP78 axis was validated by rescue experiments. Finally, a nude mice tumorigenesis experiment was carried out to analyze the effects of allicin and CBR3-AS1/miR-145-5p/GRP78 axis on the growth of living tumors. Alterations in T-lymphocyte subsets were also detected to assess the effect of allicin on OS immunoreactivity. Results: With the increase of allicin concentration, Saos-2 activity decreased and apoptosis increased (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2405-8440
Relation: http://www.sciencedirect.com/science/article/pii/S2405844024080022; https://doaj.org/toc/2405-8440
DOI: 10.1016/j.heliyon.2024.e31971
URL الوصول: https://doaj.org/article/1e3907d7c7f449a3bff2b9a5c1fed1c5
رقم الأكسشن: edsdoj.1e3907d7c7f449a3bff2b9a5c1fed1c5
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:24058440
DOI:10.1016/j.heliyon.2024.e31971