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Genomic diversity and evolution, diagnosis, prevention, and therapeutics of the pandemic COVID-19 disease

التفاصيل البيبلوغرافية
العنوان: Genomic diversity and evolution, diagnosis, prevention, and therapeutics of the pandemic COVID-19 disease
المؤلفون: M. Nazmul Hoque, Abed Chaudhury, Md Abdul Mannan Akanda, M. Anwar Hossain, Md Tofazzal Islam
المصدر: PeerJ, Vol 8, p e9689 (2020)
بيانات النشر: PeerJ Inc., 2020.
سنة النشر: 2020
المجموعة: LCC:Medicine
LCC:Biology (General)
مصطلحات موضوعية: SARS-CoV-2, Genetic diversity, Genome evolution, Diagnostics, Therapeutics, Vaccines, Medicine, Biology (General), QH301-705.5
الوصف: The coronavirus disease 19 (COVID-19) is a highly transmittable and pathogenic viral infection caused by a novel evolutionarily divergent RNA virus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus first emerged in Wuhan, China in December 2019, and subsequently spreaded around the world. Genomic analyses revealed that this zoonotic virus may be evolved naturally but not a purposefully manipulated laboratory construct. However, currently available data are not sufficient to precisely conclude the origin of this fearsome virus. Comprehensive annotations of the whole-genomes revealed hundreds of nucleotides, and amino acids mutations, substitutions and/or deletions at different positions of the ever changing SARS-CoV-2 genome. The spike (S) glycoprotein of SARS-CoV-2 possesses a functional polybasic (furin) cleavage site at the S1-S2 boundary through the insertion of 12 nucleotides. It leads to the predicted acquisition of 3-O-linked glycan around the cleavage site. Although real-time RT-PCR methods targeting specific gene(s) have widely been used to diagnose the COVID-19 patients, however, recently developed more convenient, cheap, rapid, and specific diagnostic tools targeting antigens or CRISPR-Cas-mediated method or a newly developed plug and play method should be available for the resource-poor developing countries. A large number of candidate drugs, vaccines and therapies have shown great promise in early trials, however, these candidates of preventive or therapeutic agents have to pass a long path of trials before being released for the practical application against COVID-19. This review updates current knowledge on origin, genomic evolution, development of the diagnostic tools, and the preventive or therapeutic remedies of the COVID-19. We also discussed the future scopes for research, effective management, and surveillance of the newly emerged COVID-19 disease.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2167-8359
Relation: https://peerj.com/articles/9689.pdf; https://peerj.com/articles/9689/; https://doaj.org/toc/2167-8359
DOI: 10.7717/peerj.9689
URL الوصول: https://doaj.org/article/1ea0a18f50fd420bafd48258a2fdcba7
رقم الأكسشن: edsdoj.1ea0a18f50fd420bafd48258a2fdcba7
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:21678359
DOI:10.7717/peerj.9689