دورية أكاديمية
Epoxyalcohol Synthase Branch of Lipoxygenase Cascade
| العنوان: | Epoxyalcohol Synthase Branch of Lipoxygenase Cascade |
|---|---|
| المؤلفون: | Yana Y. Toporkova, Elena O. Smirnova, Svetlana S. Gorina |
| المصدر: | Current Issues in Molecular Biology, Vol 46, Iss 1, Pp 821-841 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | fatty acid oxidation, lipoxygenase cascade, cytochromes P450, CYP74 clan, epoxyalcohol synthase, allene oxide synthase, Biology (General), QH301-705.5 |
| الوصف: | Oxylipins are one of the most important classes of bioregulators, biosynthesized through the oxidative metabolism of unsaturated fatty acids in various aerobic organisms. Oxylipins are bioregulators that maintain homeostasis at the cellular and organismal levels. The most important oxylipins are mammalian eicosanoids and plant octadecanoids. In plants, the main source of oxylipins is the lipoxygenase cascade, the key enzymes of which are nonclassical cytochromes P450 of the CYP74 family, namely allene oxide synthases (AOSs), hydroperoxide lyases (HPLs), and divinyl ether synthases (DESs). The most well-studied plant oxylipins are jasmonates (AOS products) and traumatin and green leaf volatiles (HPL products), whereas other oxylipins remain outside of the focus of researchers’ attention. Among them, there is a large group of epoxy hydroxy fatty acids (epoxyalcohols), whose biosynthesis has remained unclear for a long time. In 2008, the first epoxyalcohol synthase of lancelet Branchiostoma floridae, BfEAS (CYP440A1), was discovered. The present review collects data on EASs discovered after BfEAS and enzymes exhibiting EAS activity along with other catalytic activities. This review also presents the results of a study on the evolutionary processes possibly occurring within the P450 superfamily as a whole. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1467-3045 1467-3037 |
| Relation: | https://www.mdpi.com/1467-3045/46/1/53; https://doaj.org/toc/1467-3037; https://doaj.org/toc/1467-3045 |
| DOI: | 10.3390/cimb46010053 |
| URL الوصول: | https://doaj.org/article/1ed06a4077c94f3da13e0f344f4afe89 |
| رقم الأكسشن: | edsdoj.1ed06a4077c94f3da13e0f344f4afe89 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14673045 14673037 |
|---|---|
| DOI: | 10.3390/cimb46010053 |