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Identification and characterization of highly divergent simian foamy viruses in a wide range of new world primates from Brazil.

التفاصيل البيبلوغرافية
العنوان: Identification and characterization of highly divergent simian foamy viruses in a wide range of new world primates from Brazil.
المؤلفون: Cláudia P Muniz, Lian L Troncoso, Miguel A Moreira, Esmeralda A Soares, Alcides Pissinatti, Cibele R Bonvicino, Héctor N Seuánez, Bechan Sharma, Hongwei Jia, Anupama Shankar, William M Switzer, André F Santos, Marcelo A Soares
المصدر: PLoS ONE, Vol 8, Iss 7, p e67568 (2013)
بيانات النشر: Public Library of Science (PLoS), 2013.
سنة النشر: 2013
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Foamy viruses naturally infect a wide range of mammals, including Old World (OWP) and New World primates (NWP), which are collectively called simian foamy viruses (SFV). While NWP species in Central and South America are highly diverse, only SFV from captive marmoset, spider monkey, and squirrel monkey have been genetically characterized and the molecular epidemiology of SFV infection in NWPs remains unknown. We tested a large collection of genomic DNA (n = 332) comprising 14 genera of NWP species for the presence of SFV polymerase (pol) sequences using generic PCR primers. Further molecular characterization of positive samples was carried out by LTR-gag and larger pol sequence analysis. We identified novel SFVs infecting nine NWP genera. Prevalence rates varied between 14-30% in different species for which at least 10 specimens were tested. High SFV genetic diversity among NWP up to 50% in LTR-gag and 40% in pol was revealed by intragenus and intrafamilial comparisons. Two different SFV strains infecting two captive yellow-breasted capuchins did not group in species-specific lineages but rather clustered with SFVs from marmoset and spider monkeys, indicating independent cross-species transmission events. We describe the first SFV epidemiology study of NWP, and the first evidence of SFV infection in wild NWPs. We also document a wide distribution of distinct SFVs in 14 NWP genera, including two novel co-speciating SFVs in capuchins and howler monkeys, suggestive of an ancient evolutionary history in NWPs for at least 28 million years. A high SFV genetic diversity was seen among NWP, yet these viruses seem able to jump between NWP species and even genera. Our results raise concerns for the risk of zoonotic transmission of NWP SFV to humans as these primates are regularly hunted for food or kept as pets in forest regions of South America.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC3701081?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0067568
URL الوصول: https://doaj.org/article/1edc65c2f70e48f69050c4eeaa93e27b
رقم الأكسشن: edsdoj.1edc65c2f70e48f69050c4eeaa93e27b
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0067568