دورية أكاديمية
The effect of phospho-peptide on the stability of gold nanoparticles and drug delivery
| العنوان: | The effect of phospho-peptide on the stability of gold nanoparticles and drug delivery |
|---|---|
| المؤلفون: | Zhanwu Hou, Zhen Wang, Run Liu, Hua Li, Zhengyi Zhang, Tian Su, Jeffy Yang, Huadong Liu |
| المصدر: | Journal of Nanobiotechnology, Vol 17, Iss 1, Pp 1-11 (2019) |
| بيانات النشر: | BMC, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Biotechnology LCC:Medical technology |
| مصطلحات موضوعية: | Gold nanoparticles, Phosphotyrosine, Nanoparticle stability, Drug carrier, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5 |
| الوصف: | Abstract Background Gold nanoparticles (AuNPs) have been proposed for many applications in medicine and bioanalysis. For use in all these applications, maintaining the stability of AuNPs in solution by suppressing aggregation is paramount. Herein, the effects of amino acids were investigated in stabilizing AuNPs by rationally designed peptide scaffolds. Results Compared to other tested amino acids, phosphotyrosine (pY) significantly stabilized AuNPs. Our results indicated that pY modified AuNPs presented a high level of stability in various solutions, and had good biocompatibility. When a pY-peptide was used in stabilizing AuNPs, the phosphate group could be removed by phosphatases, which subsequently caused the aggregation and the cargo release of AuNPs. In vitro study showed that AuNPs formed aggregation in a phosphatase concentration depending manner. The aggregation of AuNPs was well correlated with the enzymatic activity (R2 = 0.994). In many types of cancer, a significant increase in phosphatases has been observed. Herein, we demonstrated that cancer cells treated with pY modified AuNPs in conjunction with doxorubicin killed SGC-7901 cells with high efficiency, indicating that the pY peptide stabilized AuNPs could be used as carriers for targeted drug delivery. Conclusion In summary, pY peptides can act to stabilize AuNPs in various solutions. In addition, the aggregation of pY-AuNPs could be tuned by phosphatase. These results provide a basis for pY-AuNPs acting as potential drug carriers and anticancer efficacy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1477-3155 |
| Relation: | http://link.springer.com/article/10.1186/s12951-019-0522-y; https://doaj.org/toc/1477-3155 |
| DOI: | 10.1186/s12951-019-0522-y |
| URL الوصول: | https://doaj.org/article/1ee866289f3b431d9f132e337bc172b8 |
| رقم الأكسشن: | edsdoj.1ee866289f3b431d9f132e337bc172b8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14773155 |
|---|---|
| DOI: | 10.1186/s12951-019-0522-y |